Home Microbiology Bacterial inhibitor Clindamycin HCl For research use only.

Clindamycin HCl

Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.

Clindamycin HCl Chemical Structure

Clindamycin HCl Chemical Structure

CAS No. 21462-39-5

Purity & Quality Control

Clindamycin HCl Related Products

Biological Activity

Description Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.
Targets
50S ribosomal [1]
In vitro
In vitro Clindamycin is a classical inhibitor of bacterial protein synthesis, by binding to the 23S ribosomal RNA of the 50S ribosomal subunit. [1]
In Vivo
In vivo Clindamycin hydrochloride results in fast absorption after oral administration in dogs, with a mean absorption time (MAT) of 0.87 hour, and bioavailability is 72.55%. Clindamycin hydrochloride results in total clearance (CL) of Clindamycin after both IV and oral administration (0.503 vs. 0.458 L/h/kg) in dogs. Clindamycin hydrochloride results in volume of distribution at steady-state (IV) at 2.48 L/kg, indicating a wide distribution of clindamycin in body fluids and tissues. Clindamycin serum concentrations after IV and oral administration remain above 0.5 μg/mL approximately for 10 hours. [1] Clindamycin hydrochloride significantly reduces oral malodor from the dogs' baseline levels through 42 days. Clindamycin hydrochloride also results in significant reductions in dental plaque, dental calculus, and gingival bleeding in dogs. [2] Clindamycin hydrochloride (2.5 mg/lb), after ultrasonic scaling, root planing, and polishing (USRP) , has a significant effect on plaque and pocket depth measures of periodontal disease but not on gingivitis in canine. [3] Clindamycin hydrochloride results in complete remission ratio of 71.4% (15/21) in dogs with canine superficial bacterial pyoderma after treat within 14 to 28 days. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05926869 Completed
Acne Vulgaris
Jinnah Postgraduate Medical Centre
 August 1 2022 Phase 2
NCT05223400 Completed
Infection Bacterial
Alexandria University
 March 1 2022 --
NCT04946500 Unknown status
Prosthetic Joint Infection|Staphylococcus
University Hospital Brest
 May 15 2021 --

Chemical Information & Solubility

Molecular Weight 461.44 Formula

C18H33ClN2O5S.HCl
CAS No. 21462-39-5 SDF Download Clindamycin HCl SDF
Smiles CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)Cl.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 92 mg/mL

DMSO : 18 mg/mL ( (39.0 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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