Home Immunology & Inflammation Anti-infection inhibitor Delafloxacin (ABT-492) For research use only.

Delafloxacin (ABT-492)

Synonyms: RX-3341J, WQ-3034

Delafloxacin (ABT-492, RX-3341, WQ-3034) is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens.

Delafloxacin (ABT-492) Chemical Structure

Delafloxacin (ABT-492) Chemical Structure

CAS No. 189279-58-1

Purity & Quality Control

Batch: S155301 DMSO]88 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.70%
99.70

Delafloxacin (ABT-492) Related Products

Biological Activity

Description Delafloxacin (ABT-492, RX-3341, WQ-3034) is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03534622 Completed
Pneumonia
Melinta Therapeutics Inc.
 April 30 2018 Phase 1
NCT01283581 Completed
Skin and Subcutaneous Tissue Bacterial Infections
Melinta Therapeutics Inc.
 January 2011 Phase 2

Chemical Information & Solubility

Molecular Weight 440.76 Formula

C18H12ClF3N4O4
CAS No. 189279-58-1 SDF --
Smiles C1C(CN1C2=C(C=C3C(=C2Cl)N(C=C(C3=O)C(=O)O)C4=C(C=C(C(=N4)N)F)F)F)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 88 mg/mL ( (199.65 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
What's the difference between S1533 and S2194?

Answer:
S1533 and S2194 are two different forms of R406. S1533 is the free base form, meaning it contains only R406 molecule without a acid added to it. S2194 has an additional C6H6O3S acid on it which makes the molecule a salt form. The free base and salt forms have same biology activities. Free base has a lower molecular weight and salt form has a better solubility in DMSO.

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