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Prostaglandin Receptor

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S7211 PF-04418948 PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1.
Arteriosclerosis, Thrombosis, and Vascular Biology, May 2018, 1115-1124
bioRxiv, February 10, 2026, nan
Cancer Research Communications, August 2023, 1486-1500
S6649 E7046 (ER-886406) E7046 (ER-886406, Palupiprant, AN0025) is a selective inhibitor of the prostaglandin E2 (PGE2) receptor EP4 with IC50 of 13.5 nM and Ki of 23.14 nM.
Cells, 2025, 1992
Cancers, 2023, 4197
Cancers, 2022 Aug 26, 4134
S3726 Selexipag Selexipag (NS-304, ACT-293987) is an orally active, first-in-class, selective prostacyclin IP receptor agonist with Ki value of 260 nM for human IP, whereas Ki values > 10,000 nM are measured at the other human G-protein-coupled prostanoid receptors (EP1-4, DP, FP and TP).
J Immunother Cancer, 2024, 12(11)e009805
Biol Pharm Bull, 2022, 10.1248/bpb.b21-01057
Front Med (Lausanne), 2021, 8:742436
S6793 TG4-155 TG4-155 is a potent and selective Prostaglandin Receptor EP2(PTGER2) antagonist with Ki value of 9.9 nM.
Transl Neurodegener, 2025, 14(1):43
Elife, 2023, 12e81438
bioRxiv, 2021, 10.1101/2021.08.27.457936
S1407 Bimatoprost Bimatoprost(AGN 192024) is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
Investigative Ophthalmology & Visual Science, December 3, 2018, 5912-5923
PLoS Pathog, 2020, 16;16(3):e1008341
Investigative Ophthalmology & Visual Science, 2018, 5912-5923
S0305 RO1138452 RO1138452 (CAY10441) is a potent and selective antagonist of IP (prostacyclin, PGI2) receptor with pKi of 9.3 and 8.7 in human platelets and a recombinant IP receptor system, respectively.
Life Sciences, May 27, 2024, 122746
Chinese Journal of Natural Medicines, February 2026, nan
Chinese Journal of Natural Medicines, February 04, 2026, nan
S5056 Dinoprost tromethamine Dinoprost Tromethamine (Dinolytic, PGF2-alpha tham, Zinoprost, Prostin F2 alpha, Dinoprost Trometamol) is a synthetic analogue of the naturally occurring prostaglandin F2 alpha, which stimulates myometrial activity, relaxes the cervix, inhibits corpus luteal steroidogenesis, and induces luteolysis by direct action on the corpus luteum.
eLife, May 24, 2021, e67409
eLife, May 24, 2021, e67409
S4152 Ethamsylate Ethamsylate (Etamsylate) is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.
J Immunother Cancer, 2024, 12(11)e009805
S0325 Treprostinil sodium Treprostinil sodium is a potent agonist of DP1, EP2 and IP receptors with Ki 4.4 nM, 3.6 nM and 32 nM, respectively.
Eur J Pharm Sci, 2025, 214:107287
S6694 Grapiprant (CJ-023,423) Grapiprant (CJ-023,423, AT-001, AAT-007, RQ-00000007, CJ-23423) is a novel selective EP4 Prostaglandin Receptor inhibitor with Ki of 20 nM and 13 nM for rat EP4 receptor and human EP4 receptor, respectively.
Bone Research, March 09, 2022, 27
Bone Research, 2022, 27
Bone Res, 2022, 10(1):27