Home GPCR & G Protein Prostaglandin Receptor antagonist Laropiprant For research use only.

Laropiprant

Laropiprant is a potent and selective prostaglandin D2 (DP) receptor antagonist with a Ki value of 0.57 nM.

Laropiprant Chemical Structure

Laropiprant Chemical Structure

CAS No. 571170-77-9

Purity & Quality Control

Batch: E287301 DMSO]87 mg/mL]false]Ethanol]87 mg/mL]false]Water]Insoluble]false Purity: 99.96%
99.96

Laropiprant Related Products

Biological Activity

Description Laropiprant is a potent and selective prostaglandin D2 (DP) receptor antagonist with a Ki value of 0.57 nM.
Targets
DP1 [1]
5.7 nM(Ki)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01583647 Terminated
Hypercholesterolemia Familial|Heterozygous Familial Hypercholesterolemia
Merck Sharp & Dohme LLC
 June 2012 Phase 1
NCT01308203 Terminated
Coronary Artery Disease|Dyslipidemias
Daniel A. Siniawski|Merck Sharp & Dohme LLC|Hospital Italiano de Buenos Aires
 October 2011 Phase 4
NCT01321034 Completed
Hypercholesterolemia
Instituto Aragones de Ciencias de la Salud|Hospital Miguel Servet
 October 2011 Phase 4
NCT01126073 Completed
Coronary Heart Disease
University Medical Centre Ljubljana
 September 2010 Phase 4
NCT00664287 Withdrawn
Dyslipidemia
Merck Sharp & Dohme LLC
 September 2008 Phase 3

Chemical Information & Solubility

Molecular Weight 435.90 Formula

C21H19CIFNO4S
CAS No. 571170-77-9 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 87 mg/mL ( (199.58 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 87 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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