Home Neuronal Signaling COX inhibitor - VEGFR inhibitor Vitamin E For research use only.

Vitamin E

Synonyms: Alpha-Tocopherol, D-alpha-Tocopherol, 5,7,8-Trimethyltocol|(+)-alpha-Tocopherol

Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.

Vitamin E Chemical Structure

Vitamin E Chemical Structure

CAS No. 59-02-9

Purity & Quality Control

Vitamin E Related Products

Signaling Pathway

COX Signaling Pathways

COX Signaling Pathway

Biological Activity

Description Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.
Targets
COX [2] VEGFR [3]
In vitro
In vitro

vitamin E is capable of inducing necrosis in TC-1 cells and has antioxidant effects against nitric oxide[1].
Cell Research Cell lines TC-1 cells
Concentrations 0, 25, 50 μM
Incubation Time 18 h
Method

For in vitro cytotoxicity experiments, 1×105 TC-1 cells per well are added to 24-well plates. Eighteen hours later, tumor cells are treated with Vitamin E (0, 25, 50 μM). After 18 hours, apoptotic (Annexin V+ and 7AAD−) and necrotic (Annexin V+ and 7AAD+) cells are measured using PE Annexin V Apoptosis Detection Kit I.
In Vivo
In vivo

Vitamin E induces TC-1 cell necrosis in vivo and reduces tumor volume in TC-1 tumor-bearing mice. Vitamin E reduces myeloid derived suppressor cells(MDSCs) in tumors of TC-1 tumor-bearing mice and enhances T cell accumulation[1].
Animal Research Animal Models C57BL/6 mice 
Dosages 2 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06323538 Not yet recruiting
Dietary Exposure|Diabetes Mellitus Type 2|Cardiovascular Diseases|Bone Loss|Sustainability|Exposure|Obesity|Vitamin Deficiency|Mineral Deficiency
German Federal Institute for Risk Assessment|Max Rubner-Institut|University of Bonn|Research Institute for Plant-Based Nutrition|University of Jena|University of Regensburg|Heidelberg University|University of Vienna
 April 1 2024 --
NCT06319079 Not yet recruiting
Lactating Mothers|Infants
Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri
 March 2024 Not Applicable
NCT06058442 Recruiting
Gastrectomy
University of Leipzig
 January 24 2024 Phase 3
NCT06057597 Recruiting
Obesity|Morbid
Assistance Publique - Hôpitaux de Paris
 November 13 2023 Not Applicable
NCT06081114 Recruiting
Micronutrient Status
Johns Hopkins Bloomberg School of Public Health|International Center for Diarrheal Disease Research Bangladesh (icddrb)|Bill and Melinda Gates Foundation
 October 22 2023 Not Applicable

Chemical Information & Solubility

Molecular Weight 430.71 Formula

C29H50O2
CAS No. 59-02-9 SDF Download Vitamin E SDF
Density 0.95 g/mL at 25 °C
Smiles CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C
Storage (From the date of receipt) 2 years -80°C liquid

In vitro
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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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