Home Neuronal Signaling COX inhibitor Etoricoxib For research use only.

Etoricoxib

Synonyms: Arcoxia, MK-663, MK-0663, Tauxib, Algix, Nucoxia

Etoricoxib (Arcoxia, MK-663, MK-0663, Tauxib, Algix, Nucoxia) is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.

Etoricoxib Chemical Structure

Etoricoxib Chemical Structure

CAS No. 202409-33-4

Purity & Quality Control

Batch: S465101 DMSO]71 mg/mL]false]Ethanol]46 mg/mL]false]Water]Insoluble]false Purity: 99.61%
99.61

Etoricoxib Related Products

Signaling Pathway

COX Signaling Pathways

COX Signaling Pathway

Biological Activity

Description Etoricoxib (Arcoxia, MK-663, MK-0663, Tauxib, Algix, Nucoxia) is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.
Targets
COX-2 [1]
In Vivo
In vivo The preferential cyclooxygenase-2 inhibitor etoricoxib significantly reduces the anticonvulsant action of phenytoin and significantly increases the beneficial action of diazepam against maximal electroshock and pentylenetetrazole-induced convulsions in a mouse model[1]. Etoricoxib has the potential to act as an anti-apoptotic and anti- proliferative agent in the colon[2].
Animal Research Animal Models Adult albino male mice
Dosages 10 mg/kg
Administration p.o.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05142098 Unknown status
Effect of Drug
Dow University of Health Sciences
 January 1 2022 Early Phase 1
NCT05791721 Completed
Surgical Wound|Post Operative Pain
University of Belgrade
 October 11 2021 Phase 4
NCT02503839 Completed
Tuberculosis
Anne Margarita Dyrhol Riise|University of Oslo|Statens Serum Institut|Haukeland University Hospital|Oslo University Hospital
 November 2015 Phase 1
NCT02568735 Completed
Pain Postoperative
Kuopio University Hospital
 January 2013 Phase 4
NCT01572675 Completed
Osteoarthritis
Organon and Co
 June 2012 --

Chemical Information & Solubility

Molecular Weight 358.84 Formula

C18H15ClN2O2S
CAS No. 202409-33-4 SDF Download Etoricoxib SDF
Smiles CC1=NC=C(C=C1)C2=C(C=C(C=N2)Cl)C3=CC=C(C=C3)S(=O)(=O)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 71 mg/mL ( (197.85 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 46 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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