For research use only. Not for use in humans.

Vantictumab (Anti-FZD)

Synonyms: OMP-18R5 Cat.No.A2489 Purity:99%

Vantictumab (Anti-FZD) is a monoclonal antibody targeting the Wnt signaling pathway with potential antineoplastic activity. Vantictumab binds to certain receptors in the Wnt signaling pathway thereby preventing the activation of the Wnt signaling pathway. This results in an inhibition of cancer stem cell (CSC) activity and a subsequent inhibition of cancer cell proliferation. MW: 145.5 KD.

Quality Control

Batch: A248901 Purity: 99% Protein concentration: 5.82mg/ml Endotoxin Level: ＜1EU/mg

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

Featured Inhibitors	Y-27632 Dihydrochloride SB431542 CHIR-99021 (Laduviglusib) RMC-7977 RMC-6236 (Daraxonrasib) MRTX1133 MG132 Z-VAD-FMK VT3989 IAG933

Specificity

Name	Citation	WNT	β-catenin	Wnt/β-catenin	Others
IWR-1-endo	167	+++
IWP-2	135	+++			<sup>M82F</sup>CK1δ
JW74	1	++
IWP-4	1			++++
CCT251545	3	++++			CDK19,CDK8
KY1220	0			+	Ras
iCRT14	5		+
iCRT3	10			++++
LF3	20		++
PNU-74654	24			+++
KYA1797K	16			++
KY02111	9	✔
Zamaporvint (RXC004)	0	✔
M2912	0	✔			TNKS2,TNKS1,axin2
M435-1279	1			✔
KY-05009	1	✔			TNIK
Prodigiosin	0			✔
Ginsenoside Rh4	0			✔
Heparan Sulfate	10	✔
RCM-1	5		✔		FOXM1,STAT6,IL-13
Resibufogenin	3		✔		Caspase-3,ROS,p-GSK3β
MSAB	9		✔
PRI-724 (Foscenvivint)	32		✔		CBP
Tegatrabetan (BC-2059)	4		✔
JW55	3	✔
Adavivint (SM04690)	8	✔
Triptonide	2			✔
Isoquercitrin	6			✔
IQ-1	4		✔
Salinomycin (Procoxacin)	22			✔
FH535	20			✔	PPARδ,PPARγ

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Vantictumab (Anti-FZD) is a monoclonal antibody targeting the Wnt signaling pathway with potential antineoplastic activity. Vantictumab binds to certain receptors in the Wnt signaling pathway thereby preventing the activation of the Wnt signaling pathway. This results in an inhibition of cancer stem cell (CSC) activity and a subsequent inhibition of cancer cell proliferation. MW: 145.5 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1345009-45-1
Molecular Weight	145.5 kDa
Isotype	Human IgG2SA
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.