Vantictumab (Anti-FZD)

Synonyms: OMP-18R5

Catalog No.A2489 Purity:99%

Vantictumab (Anti-FZD) is a monoclonal antibody targeting the Wnt signaling pathway with potential antineoplastic activity. Vantictumab binds to certain receptors in the Wnt signaling pathway thereby preventing the activation of the Wnt signaling pathway. This results in an inhibition of cancer stem cell (CSC) activity and a subsequent inhibition of cancer cell proliferation. MW: 145.5 KD.

Purity & Quality Control

Batch: A248901 Purity: 99% Protein concentration: 5.82mg/ml Endotoxin Level: ＜1EU/mg

Choose Selective Wnt/beta-catenin Inhibitors

Name	Citation	WNT	β-catenin	Wnt/β-catenin	Others
IWR-1-endo	131	+++
IWP-2	105	+++			<sup>M82F</sup>CK1δ
JW74	1	++
IWP-4	0			++++
CCT251545	3	++++			CDK19,CDK8
KY1220	0			+	Ras
iCRT14	4		+
iCRT3	9			++++
LF3	17		++
PNU-74654	20			+++
KYA1797K	14			++
KY02111	✔
Zamaporvint (RXC004)	✔
M2912	✔			TNKS2,TNKS1,axin2
M435-1279			✔
KY-05009	✔			TNIK
Prodigiosin			✔
Ginsenoside Rh4			✔
Heparan Sulfate	✔
RCM-1		✔		STAT6,IL-13,FOXM1
Resibufogenin		✔		RIP3,PI3K,cyclin E
MSAB		✔
PRI-724		✔		CBP
Tegatrabetan (BC-2059)		✔
JW55	✔
Adavivint (SM04690)	✔
Triptonide			✔
Isoquercitrin			✔
IQ-1		✔
Salinomycin (from Streptomyces albus)			✔
FH535			✔	PPARγ,PPARδ

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Vantictumab (Anti-FZD) is a monoclonal antibody targeting the Wnt signaling pathway with potential antineoplastic activity. Vantictumab binds to certain receptors in the Wnt signaling pathway thereby preventing the activation of the Wnt signaling pathway. This results in an inhibition of cancer stem cell (CSC) activity and a subsequent inhibition of cancer cell proliferation. MW: 145.5 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1345009-45-1
Molecular Weight	145.5 kDa
Isotype	Human IgG2SA
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100mMPro-Ac,20mMArg-Ac，pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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