Home Apoptosis RIP kinase activator - Mixed Lineage Kinase activator - ROS activator - Apoptosis related activator - Caspase activator - Bcl-2 activator - CDK inhibitor - PI3K inhibitor - Akt inhibitor - GSK-3 inhibitor - Wnt/beta-catenin inhibitor Resibufogenin For research use only.

Resibufogenin

Synonyms: Bufogenin, Recibufogenin

Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.

Resibufogenin Chemical Structure

Resibufogenin Chemical Structure

CAS No. 465-39-4

Purity & Quality Control

Resibufogenin Related Products

Biological Activity

Description Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.
Targets
RIP3 [1] MLK [1] ROS [1] Caspase-3 [2] Caspase-8 [2] Click to View More Targets

Chemical Information & Solubility

Molecular Weight 384.51 Formula

C24H32O4
CAS No. 465-39-4 SDF --
Smiles CC12CCC(O)CC1CCC3C2CCC4(C)C(CC5OC345)C6=COC(=O)C=C6
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 77 mg/mL ( (200.25 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 77 mg/mL

Water : Insoluble


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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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