Home Neuronal Signaling 5-HT Receptor antagonist Trazodone For research use only.

Trazodone

Synonyms: AF-1161

Trazodone (AF-1161) is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders.

Trazodone Chemical Structure

Trazodone Chemical Structure

CAS No. 19794-93-5

Purity & Quality Control

Batch: S585701 DMSO]45 mg/mL]false]Ethanol]17 mg/mL]false]Water]Insoluble]false Purity: 98.98%
98.98

Trazodone Related Products

Signaling Pathway

5-HT Receptor Signaling Pathways

5-HT Receptor Signaling Pathway

Biological Activity

Description Trazodone (AF-1161) is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06286189 Recruiting
Obstructive Sleep Apnea
Brigham and Women''s Hospital
 January 1 2024 Phase 1|Phase 2
NCT02086929 Completed
Major Depressive Disorder
Aziende Chimiche Riunite Angelini Francesco S.p.A
 December 2012 Phase 3
NCT01097980 Completed
Sexual Dysfunction
Beitou Armed Forces Hospital Taipei Taiwan
 April 2010 Not Applicable

Chemical Information & Solubility

Molecular Weight 371.86 Formula

C19H22ClN5O
CAS No. 19794-93-5 SDF --
Smiles C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 45 mg/mL ( (121.01 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 17 mg/mL

Water : Insoluble


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In vivo
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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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