Home Neuronal Signaling 5-HT Receptor antagonist Puerarin For research use only.

Puerarin

Synonyms: Kakonein

Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.

Puerarin Chemical Structure

Puerarin Chemical Structure

CAS No. 3681-99-0

Purity & Quality Control

Batch: S234601 DMSO]86 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.80%
99.80

Puerarin Related Products

Signaling Pathway

5-HT Receptor Signaling Pathways

5-HT Receptor Signaling Pathway

Biological Activity

Description Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.
In vitro
In vitro Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. [1] Pueraria is employed clinically to treat cardiovascular diseases in China. [2] Another study showed that puerarin also possessed anti-cancer properties. Puerarin at 25 μM dose-dependently reduces HT-29 cellular growth with an increase of bax and decreases of c-myc and bcl-2. [3]
In Vivo
In vivo In hypercholesterolmic diet plus administration of puerarin (300 mg/kg/day, p.o.) rats, Puerarin markedly attenuated the increased total cholesterol induced by hypercholesterolmic diet in both serum and liver. [2] LD50: Mice 738mg/kg (i.v.) [4]

Chemical Information & Solubility

Molecular Weight 416.38 Formula

C21H20O9
CAS No. 3681-99-0 SDF Download Puerarin SDF
Smiles C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3C4C(C(C(C(O4)CO)O)O)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 86 mg/mL ( (206.54 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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