Home Immunology & Inflammation COX inhibitor Tolmetin Sodium For research use only.

Tolmetin Sodium

Synonyms: MCN2559

Tolmetin(MCN2559) is a non-steroidal anti-inflammatory drug of the arylalkanoic acids. Tolmetin sodium dihydrate is a non-steroidal antiinflammatory agent, and acts as a non-selective COX inhibitor.

Tolmetin Sodium Chemical Structure

Tolmetin Sodium Chemical Structure

CAS No. 64490-92-2

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Tolmetin Sodium Related Products

Signaling Pathway

COX Signaling Pathways

COX Signaling Pathway

Biological Activity

Description Tolmetin(MCN2559) is a non-steroidal anti-inflammatory drug of the arylalkanoic acids. Tolmetin sodium dihydrate is a non-steroidal antiinflammatory agent, and acts as a non-selective COX inhibitor.
In vitro
In vitro

Tolmetin is a nonsteroidal antiinflammatory drug (NSAID) which is useful in the treatment of rheumatoid arthritis, osteoarthritis, and gout. Tolmetin induces prostaglandin synthesis inhibition in vitro with IC50 of 3 mg/mL. [1]
In Vivo
In vivo

Tolmetin (100 mg/kg, po) produces a dose-dependent antinociceptive effect in rats received an intra-articular injection of uric acid in the right hindlimb, which is not directly related to blood concentration. [1] Tolmetin (100 mg/kg i.p.) is metabolized into tolmetin acyl-CoA (Tol-CoA), the acyl-CoA-dependent metabolites tolmetin-taurine conjugate (Tol-Tau) and tolmetin-acyl carnitine ester (Tol-Car) in liver homogenates of rats. [2] Tolmetin sodium (1 mg/mL in 5-15 mL) is consistently efficacious in reducing postoperative adhesion formation in uterine horn and peritoneal side wall of rabbits. Tolmetin sodium (1 mg/mL in 3 mL) is consistently efficacious in reducing postoperative adhesion formation in uterine horn and peritoneal side wall of rats. [3] Tolmetin (0.5-2.0 mg/mL) combined with hyaluronic acid is efficacious in reducing adhesion formation in a standardized rabbit model. [4] Tolmetin sodium (100 mg/kg, i.p.) transiently decreases the phagocytic capability of peritoneal leukocytes in normal rats. Tolmetin (100 mg/kg, i.p.) significantly elevates superoxide anion release at days 3 and 5, phagocytosis at days 7 and 14 and tumoricidal activity at day 3 in normal rats. [5]

Chemical Information & Solubility

Molecular Weight 315.3 Formula

C15H14NO3.Na.2H2O
CAS No. 64490-92-2 SDF Download Tolmetin Sodium SDF
Smiles CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)[O-].O.O.[Na+]
Storage (From the date of receipt)

In vitro
Batch:

Water : 63 mg/mL

Ethanol : 10 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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