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Technical Data
| Formula | C15H14NO3.Na.2H2O |
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| Molecular Weight | 315.3 | CAS No. | 64490-92-2 | |
| Solubility (25°C)* | In vitro | Water | 63 mg/mL (199.8 mM) | |
| Ethanol | 10 mg/mL (31.71 mM) | |||
| DMSO | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Tolmetin(MCN2559) is a non-steroidal anti-inflammatory drug of the arylalkanoic acids. Tolmetin sodium dihydrate is a non-steroidal antiinflammatory agent, and acts as a non-selective COX inhibitor. |
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| In vitro | Tolmetin is a nonsteroidal antiinflammatory drug (NSAID) which is useful in the treatment of rheumatoid arthritis, osteoarthritis, and gout. Tolmetin induces prostaglandin synthesis inhibition in vitro with IC50 of 3 mg/mL. [1] |
| In vivo | Tolmetin (100 mg/kg, po) produces a dose-dependent antinociceptive effect in rats received an intra-articular injection of uric acid in the right hindlimb, which is not directly related to blood concentration. [1] Tolmetin (100 mg/kg i.p.) is metabolized into tolmetin acyl-CoA (Tol-CoA), the acyl-CoA-dependent metabolites tolmetin-taurine conjugate (Tol-Tau) and tolmetin-acyl carnitine ester (Tol-Car) in liver homogenates of rats. [2] Tolmetin sodium (1 mg/mL in 5-15 mL) is consistently efficacious in reducing postoperative adhesion formation in uterine horn and peritoneal side wall of rabbits. Tolmetin sodium (1 mg/mL in 3 mL) is consistently efficacious in reducing postoperative adhesion formation in uterine horn and peritoneal side wall of rats. [3] Tolmetin (0.5-2.0 mg/mL) combined with hyaluronic acid is efficacious in reducing adhesion formation in a standardized rabbit model. [4] Tolmetin sodium (100 mg/kg, i.p.) transiently decreases the phagocytic capability of peritoneal leukocytes in normal rats. Tolmetin (100 mg/kg, i.p.) significantly elevates superoxide anion release at days 3 and 5, phagocytosis at days 7 and 14 and tumoricidal activity at day 3 in normal rats. [5] |
Protocol (from reference)
References
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.