Home Neuronal Signaling NMDAR agonist (R)-Serine For research use only.

(R)-Serine

(R)-Serine is the R-enantiomer of serine, which is used in the biosynthesis of proteins. (R)-Serine acts as obligatory coagonist at the glycine site associated with the N-methyl-D-aspartate subtype of glutamate receptors (NMDAR) and has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.

(R)-Serine Chemical Structure

(R)-Serine Chemical Structure

CAS No. 312-84-5

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(R)-Serine Related Products

Biological Activity

Description (R)-Serine is the R-enantiomer of serine, which is used in the biosynthesis of proteins. (R)-Serine acts as obligatory coagonist at the glycine site associated with the N-methyl-D-aspartate subtype of glutamate receptors (NMDAR) and has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03359785 Completed
Schizophrenia
Neurocrine Biosciences|Takeda
 January 10 2018 Phase 2
NCT02716987 Completed
Healthy
Neurocrine Biosciences|Takeda
 March 21 2016 Phase 1
NCT01018056 Completed
Tourette Syndrome
Johns Hopkins University|National Institute of Mental Health (NIMH)
 November 2009 Phase 4
NCT00789022 Unknown status
Schizophrenia|Schizophreniform|Schizoaffective Disorder|Brief Psychotic Episode
Shalvata Mental Health Center
 January 2009 --

Chemical Information & Solubility

Molecular Weight 105.09 Formula

C3H7NO3
CAS No. 312-84-5 SDF --
Smiles C(C(C(=O)O)N)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 21 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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