Home Neuronal Signaling Dopamine Receptor agonist Pramipexole dihydrochloride For research use only.

Pramipexole dihydrochloride

Synonyms: SND919

Pramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.

Pramipexole dihydrochloride Chemical Structure

Pramipexole dihydrochloride Chemical Structure

CAS No. 104632-25-9

Purity & Quality Control

Batch: S506601 DMSO]56 mg/mL]false]]]false]]]false Purity: 98%
98

Pramipexole dihydrochloride Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description Pramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.
Targets
D3 receptor [1]
(Cell-free)		 D2L Receptor [1]
(Cell-free)		 D2S Receptor [1]
(Cell-free)		 D4 receptor [1]
(Cell-free)
0.5 nM(Ki) 2.2 nM(Ki) 3.9 nM(Ki) 5.1 nM(Ki)
In Vivo
In vivo In mice, pramipexole (0.001-1 mg/kg s.c.) reduced exploratory locomotor activity. In rats with unilateral striatal lesions, only weak ipsilateral rotation was produced by pramipexole at the highest dose. However, in rats with unilateral lesions of the medial forebrain bundle, pramipexole potently induced contralateral circling (ED50 0.026 mg/kg s.c). In the N-mcthyl-4-phenyl-l,2,3,6 tetrahydropyridine (MPTP) monkey model, pramipexole also had potent stimulatory effects[2]. Pramipexole is, at least in part, transported across the BBB by an organic cation-sensitive transporter. The pramipexole transport is pH-dependent, but sodium- and membrane potential-independent[3].
Animal Research Animal Models Male mice
Dosages 0.001-1 mg/kg
Administration p.o.

Chemical Information & Solubility

Molecular Weight 284.25 Formula

C10H17N3S.2HCl
CAS No. 104632-25-9 SDF --
Smiles CCCNC1CCC2=C(C1)SC(=N2)N.Cl.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 56 mg/mL ( (197.0 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Pramipexole dihydrochloride | Pramipexole dihydrochloride ic50 | Pramipexole dihydrochloride price | Pramipexole dihydrochloride cost | Pramipexole dihydrochloride solubility dmso | Pramipexole dihydrochloride purchase | Pramipexole dihydrochloride manufacturer | Pramipexole dihydrochloride research buy | Pramipexole dihydrochloride order | Pramipexole dihydrochloride mouse | Pramipexole dihydrochloride chemical structure | Pramipexole dihydrochloride mw | Pramipexole dihydrochloride molecular weight | Pramipexole dihydrochloride datasheet | Pramipexole dihydrochloride supplier | Pramipexole dihydrochloride in vitro | Pramipexole dihydrochloride cell line | Pramipexole dihydrochloride concentration | Pramipexole dihydrochloride nmr