Home Immunology & Inflammation PD-1/PD-L1 inhibitor PD-1/PD-L1 Inhibitor 3 For research use only.

PD-1/PD-L1 Inhibitor 3

PD-1/PD-L1 Inhibitor 3（Programmed Death-1/Programmed Death-Ligand 1 Inhibitor 3）is a Macrocyclic inhibitor of PD-1/PD-L1 interaction with IC50 of 5.6 nM

PD-1/PD-L1 Inhibitor 3 Chemical Structure

PD-1/PD-L1 Inhibitor 3 Chemical Structure

CAS No. 1629654-95-0

Purity & Quality Control

PD-1/PD-L1 Inhibitor 3 Related Products

Biological Activity

Description PD-1/PD-L1 Inhibitor 3（Programmed Death-1/Programmed Death-Ligand 1 Inhibitor 3）is a Macrocyclic inhibitor of PD-1/PD-L1 interaction with IC50 of 5.6 nM
Targets
PD-1/PD-L1 interaction [1]
(Cell-free assay)
5.6 nM
In vitro
In vitro

PD-1/PD-L1 Inhibitor 3 is capable of inhibiting the interaction of PD-L1 with PD-1 and with CD80. It has highly efficacious binding to PD-L1 and promotes enhanced T cell functional activity[1].

Chemical Information & Solubility

Molecular Weight 1852.17 Formula

C89H126N24O18S
CAS No. 1629654-95-0 SDF Download PD-1/PD-L1 Inhibitor 3 SDF
Smiles CCCCC1C(=O)NC(C(=O)NC(CSCC(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)N(CC(=O)NC(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N1C)CCCC)C)CC3=CNC4=CC=CC=C43)CO)CC5=CNC6=CC=CC=C65)C)CC(C)C)CC7=CN=CN7)CC(=O)N)C)C)CC8=CC=CC=C8)C(=O)NCC(=O)N)CCCNC(=N)N
Storage (From the date of receipt)

In vitro
Batch:

Water : 100 mg/mL


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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Frequently Asked Questions

Question 1:
Could you tell me what the difference is between these products (S7911, S7912, S8158), and do you have any recommendations about which one to select?

Answer:
The products are of high purity and can be used for both cell culture and mouse study. S7911 and S7912 are small-molecule inhibitors that have different IC50s, while S8158 is a macrocyclic inhibitor.

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