PD-1/PD-L1 Inhibitor 3

Catalog No.S8158 Batch:S815803

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Technical Data

Formula

C89H126N24O18S
Molecular Weight 1852.17 CAS No. 1629654-95-0
Solubility (25°C)* In vitro Water 100 mg/mL (53.99 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description PD-1/PD-L1 Inhibitor 3（Programmed Death-1/Programmed Death-Ligand 1 Inhibitor 3）is a Macrocyclic inhibitor of PD-1/PD-L1 interaction with IC50 of 5.6 nM
Targets
PD-1/PD-L1 interaction [1]
(Cell-free assay)
5.6 nM
In vitro

PD-1/PD-L1 Inhibitor 3 is capable of inhibiting the interaction of PD-L1 with PD-1 and with CD80. It has highly efficacious binding to PD-L1 and promotes enhanced T cell functional activity[1].

Protocol (from reference)

Selleck's PD-1/PD-L1 Inhibitor 3 has been cited by 13 publications

Microphysiologically Engineered Vessel-Tumor Model to Investigate Vascular Transport Dynamics of Immune Cells [ ACS Appl Mater Interfaces, 2024, 16(18):22839-49] PubMed: 38652824
Development and In Vivo Evaluation of Small-Molecule Ligands for Positron Emission Tomography of Immune Checkpoint Modulation Targeting Programmed Cell Death 1 Ligand 1 [ J Med Chem, 2024, 67(5):4036-4062] PubMed: 38442487
On the Road towards Small-Molecule Programmed Cell Death 1 Ligand 1 Positron Emission Tomography Tracers: A Ligand-Based Drug Design Approach [ Pharmaceuticals (Basel), 2023, 16(7)1051] PubMed: 37513962
Myricetin inhibits interferon-γ-induced PD-L1 and IDO1 expression in lung cancer cells [ Biochem Pharmacol, 2022, 197:114940] PubMed: 35120895
Myricetin inhibits interferon-γ-induced PD-L1 and IDO1 expression in lung cancer cells [ Biochem Pharmacol, 2022, 197:114940] PubMed: 35120895
FAK Regulates VEGFR2 Expression and Promotes Angiogenesis in Triple-Negative Breast Cancer [ ChemMedChem, 2022, e202200091] PubMed: 35388635
A mating mechanism to generate diversity for the Darwinian selection of DNA-encoded synthetic molecules [ Nat Chem, 2021, 10.1038/s41557-021-00829-5] PubMed: 34873299
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β [ Exp Mol Med, 2021, 53(9):1366-1378] PubMed: 34548615
The Stone Guest: How Does pH Affect Binding Properties of PD-1/PD-L1 Inhibitors [ ChemMedChem, 2021, 16(3):568-577] PubMed: 33085193
Blockade of Kv1.3 potassium channel inhibits CD8+ T cell-mediated neuroinflammation via PD-1/Blimp-1 signaling [ FASEB J, 2020, 10.1096/fj.202000861RR] PubMed: 32981181

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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