Home Immunology & Inflammation PD-1/PD-L1 inhibitor BMS202 For research use only.

BMS202

Synonyms: PD-1/PD-L1 inhibitor 2

BMS202 is a small-molecule PD-1/PD-L1 interaction inhibitor with IC50 of 18 nM.

BMS202 Chemical Structure

BMS202 Chemical Structure

CAS No. 1675203-84-5

Purity & Quality Control

BMS202 Related Products

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BL21(DE3) Function assay Binding affinity to [15N-Tyr]-labeled human PD-L1 (18 to 134 residues) expressed in Escherichia coli BL21(DE3) by 1H-15N 2D HMQC NMR spectroscopic analysis. 28613862
BL21(DE3) Function assay Binding affinity to [15N-Val]-labeled human PD-L1 (18 to 134 residues) expressed in Escherichia coli BL21(DE3) by 1H-15N 2D HMQC NMR spectroscopic analysis. 28613862
Click to View More Cell Line Experimental Data

Biological Activity

Description BMS202 is a small-molecule PD-1/PD-L1 interaction inhibitor with IC50 of 18 nM.
Targets
PD-1/PD-L1 interaction [2]
(Cell-free assay)
0.018 μM
In vitro
In vitro

BMS-202 inhibits PD-1/PD-L1 binding in SCC-3 and Jurkat cells with IC50 of 15 μM and 10 μM, respectively.
Cell Research Cell lines SCC-3 and Jurkat cells
Concentrations IC50 of 15 μM and 10 μM
Incubation Time 4 days
Method

Cells were treated with various concentrations of drug for 4 days.
In Vivo
In vivo

BMS-202 treatment shows a clear antitumor effect compared with the controls, in humanized MHC- dKO NOG mice.
Animal Research Animal Models NOG-dKO mice
Dosages 20 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 419.52 Formula

C25H29N3O3
CAS No. 1675203-84-5 SDF Download BMS202 SDF
Smiles CC1=C(C=CC=C1C2=CC=CC=C2)COC3=NC(=C(C=C3)CNCCNC(=O)C)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 83 mg/mL ( (197.84 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 83 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
I would like to know the difference of S8158, S7912, S7911, and the reason of why the IC50 is different.

Answer:
These three compounds are three different PD-l/PD-L1 inhibitors. They have different structures, characteristics, and probably function through different mechanisms. And this is why the IC50s are different. Inhibitor 1 and 2 are small-molecule inhibitors while inhibitor 3 is Macrocyclic inhibitor.

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