Home Neuronal Signaling Dopamine Receptor antagonist Metoclopramide For research use only.

Metoclopramide

Metoclopramide is a dopamine antagonist used for the treatment of nausea and vomiting.

Metoclopramide Chemical Structure

Metoclopramide Chemical Structure

CAS No. 364-62-5

Purity & Quality Control

Batch: S586201 DMSO]60 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.95%
99.95

Metoclopramide Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description Metoclopramide is a dopamine antagonist used for the treatment of nausea and vomiting.
Targets
Dopamine receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05759481 Recruiting
Post-operative Nausea and Vomiting
Milton S. Hershey Medical Center
 February 1 2024 Phase 2
NCT06297954 Recruiting
Upper Gastrointestinal Bleeding
Universidad Autonoma de Nuevo Leon
 March 16 2023 Phase 3
NCT05832151 Recruiting
Diabetic Gastroparesis
CinDome Pharma Inc.
 March 27 2023 Phase 2
NCT05008926 Recruiting
Brain Injuries
University Hospital Brest
 March 15 2022 Phase 3
NCT04748133 Unknown status
Treatment Complication
Zagazig University
 February 20 2021 Not Applicable

Chemical Information & Solubility

Molecular Weight 299.80 Formula

C14H22ClN3O2
CAS No. 364-62-5 SDF --
Smiles CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 60 mg/mL ( (200.13 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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