Home Immunology & Inflammation PD-1/PD-L1 inhibitor INCB086550 For research use only.

INCB086550

Synonyms: PD-1/PD-L1-IN-8

INCB086550 (PD-1/PD-L1-IN-8) is a potent PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM. INCB086550 binds to PD-L1 and interrupts its interaction with PD-1 and also induces PD-L1 dimerization and internalization.

INCB086550 Chemical Structure

INCB086550 Chemical Structure

CAS No. 2230911-59-6

Purity & Quality Control

INCB086550 Related Products

Biological Activity

Description INCB086550 (PD-1/PD-L1-IN-8) is a potent PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM. INCB086550 binds to PD-L1 and interrupts its interaction with PD-1 and also induces PD-L1 dimerization and internalization.
Targets
PD-1/PD-L1 [1]
<10 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05101369 Completed
Healthy Volunteers
Incyte Corporation
 January 21 2022 Phase 1
NCT03762447 Completed
Solid Tumors
Incyte Corporation
 December 10 2018 Phase 1

Chemical Information & Solubility

Molecular Weight 693.79 Formula

C41H39N7O4
CAS No. 2230911-59-6 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (144.13 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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