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Idebenone

Synonyms: CV-2619

Idebenone (CV-2619) is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.

Idebenone Chemical Structure

Idebenone Chemical Structure

CAS No. 58186-27-9

Purity & Quality Control

Idebenone Related Products

Biological Activity

Description Idebenone (CV-2619) is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.
In vitro
In vitro Idebenone effectively protects from retinal cell injury after oxidative stress or hypoglycemia, whereas the protection afforded after postincubation of both antioxidants is decreased. Idebenone attenuates delayed retinal cell damage, mediated by chemical ischemia. [1] Idebenone, a centrally active antioxidant used to treat multiinfarct dementia, protects cells from this form of glutamate-induced cytotoxicity in vitro. Idebenone provides significant protection against the neuronal degeneration induced by intrastriatal injection of kainic acid and quisqualic acid, but not the NMDA receptor agonist, quinolinic acid. [2]
In Vivo
In vivo Idebenone prevents the behavioural deficits in Y-maze and water maze, but not passive avoidance, tasks in A beta-(1-42)-infused rats when they are repeatedly administered by mouth once a day from 3 days before the start of A beta infusion to the end of behavioural experiments. [3] Idebenone (100 and 300 mg/kg) is orally administered to rats for 3 days, it increases the state 3 respiration stimulated by ADP, slightly decreasez the state 4 respiration after the consumption of ADP and resultz in a significant increase of the respiratory control index (RCI) by 14-19% for glutamate oxidation and 10-17% for succinate oxidation, respectively. Idebenone significantly suppresses by about 10% the non-respiratory oxygen consumption, which closely associated with non-enzymatic reactions such as lipid peroxidation, membrane lysis and swelling of mitochondria. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01303406 Completed
Friedreich''s Ataxia
Santhera Pharmaceuticals
 April 2011 Phase 3
NCT00758225 Completed
Duchenne Muscular Dystrophy
Santhera Pharmaceuticals
 September 2008 Phase 2
NCT00747487 Completed
Leber''s Hereditary Optic Neuropathy
Santhera Pharmaceuticals
 November 2007 Phase 2
NCT00229632 Completed
Friedreich Ataxia
National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC)
 September 27 2005 Phase 2

Chemical Information & Solubility

Molecular Weight 338.44 Formula

C19H30O5
CAS No. 58186-27-9 SDF Download Idebenone SDF
Smiles CC1=C(C(=O)C(=C(C1=O)OC)OC)CCCCCCCCCCO
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 68 mg/mL ( (200.92 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 68 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

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