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Gallic acid

Synonyms: 3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid

Gallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid), known as powerful antioxidants, is an organic acid found in a variety of foods and herbs.

Gallic acid Chemical Structure

Gallic acid Chemical Structure

CAS No. 149-91-7

Purity & Quality Control

Gallic acid Related Products

Biological Activity

Description Gallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid), known as powerful antioxidants, is an organic acid found in a variety of foods and herbs.
In vitro
In vitro Gallic acid does not protect against H(2)O(2)-induced PC12 cell death. It reduced the viability of PC12 cells in a dose-dependent manner. Gallic acid also induces cleavage of poly (ADP-ribose) polymerase, which is strongly related to apoptosis in neurons. Gallic acid induces the phosphorylation of c-Jun N-terminal protein kinase (JNK) and the downregulation of Bcl-2 in PC12 cells. Gallic acid leads to a progressive reduction in the viability of vector-transfected PC12 cells, which is delayed in PC12 cells that overexpressed Bcl-2[2].
Cell Research Cell lines PC12 cells
Concentrations 25 or 50 μM
Incubation Time 24 h
Method Cell viability is measured using the MTT assay. PC12 cells are incubated at 37◦C with H2O2 or gallic acid at different concentrations for 24 h with or without pretreatment with resveratrol. They are then treated with the MTT solution (final concentration, 1 mg/mL) for 2 h. The dark-blue formazan crystals that formed in intact cells are dissolved in DMSO, and the absorbance at 570 nm is measured using a micro-ELISA reader.
In Vivo
In vivo Gallic acid effectively protects rat erythrocytes. The antioxidant effect of the compound at the tested dosage in vivo was more prevalent than its prooxidative effects. Gallic acid has ameliorative effect on lipid peroxidation in vivo[1].
Animal Research Animal Models Male Wistar rats
Dosages 10 mg/kg and 20 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03413735 Unknown status
Obesity|Endotoxemia|Inflammation
Ohio State University
 August 29 2018 Not Applicable
NCT02779361 Completed
Healthy Volunteers|Doping in Sports
Parc de Salut Mar|World Anti-Doping Agency
 January 2016 Phase 1
NCT02008721 Completed
Multiple System Atrophy
Dr. Johannes Levin|German Center for Neurodegenerative Diseases (DZNE)|Deutsche Parkinson Vereinigung|German Foundation for Neurology|ParkinsonFonds Deutschland gGmbH|Ludwig-Maximilians - University of Munich
 January 2014 Phase 3

Chemical Information & Solubility

Molecular Weight 170.12 Formula

C7H6O5
CAS No. 149-91-7 SDF Download Gallic acid SDF
Smiles C1=C(C=C(C(=C1O)O)O)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 34 mg/mL ( (199.85 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 34 mg/mL

Water : 7 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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