Home Cytoskeletal Signaling HSP (HSP90) activator HSF1A For research use only.

HSF1A

HSF1A is a cell-permeable heat shock transcription factor 1 (HSF1) activator. HSF1A protects cells from stress-induced apoptosis, binds TRiC subunits and inhibits TRiC activity without perturbation of ATP hydrolysis.

HSF1A Chemical Structure

HSF1A Chemical Structure

CAS No. 1196723-93-9

Purity & Quality Control

HSF1A Related Products

Signaling Pathway

HSP (HSP90) Signaling Pathways

HSP (HSP90) Signaling Pathway

Biological Activity

Description HSF1A is a cell-permeable heat shock transcription factor 1 (HSF1) activator. HSF1A protects cells from stress-induced apoptosis, binds TRiC subunits and inhibits TRiC activity without perturbation of ATP hydrolysis.
In vitro
In vitro

HSF1A, an HSF1 activator, alleviates DOX-induced cardiomyocyte apoptosis via suppression of the IGF-IIR apoptotic signaling pathway.[1]
Cell Research Cell lines H9c2 cells, Neonatal rat ventricular myocytes (NRVMs)
Concentrations 10 μM
Incubation Time 24 h
Method

After treatments of HSF1A for 24 h, H9c2 cells and NRVMs are fixed with a 4% paraformaldehyde solution for 30 min. Following a rinse with PBS, the samples are incubated first with phalloidin–rhodamine for 1 h and subsequently with the TUNEL reaction mixture, containing terminal deoxynucleotidyl transferase and Resorcinolphthalein isothiocyanate-dUTP.
In Vivo
In vivo

HSF1A enhances HSF1 activity, stabilizes HSF1 expression and minimizes Doxorubicin (DOX)-induced cardiac damage. WKY rats are challenged with DOX (accumulated dose: 30 mg/kgw), and DOX combined with HSF1A. Supplementation with HSF1A significantly elevates cardiac functions back to the levels of the control group. HSF1A has been shown to stimulate human HSF1 nuclear translocation, elevate protein chaperone expression and ameliorate protein misfolding and cell death in a neurodegenerative disease model. The echocardiographic results show that HSF1A also alleviates DOX-induced failures in cardiac function.

Chemical Information & Solubility

Molecular Weight 409.52 Formula

C21H19N3O2S2
CAS No. 1196723-93-9 SDF --
Smiles CCC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=NN2C3=CC=CC=C3)C4=CC=CS4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 82 mg/mL ( (200.23 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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