Home Cytoskeletal Signaling HSP (HSP90) inhibitor - Apoptosis related activator JG98 For research use only.

JG98

JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.

JG98 Chemical Structure

JG98 Chemical Structure

CAS No. 1456551-16-8

Purity & Quality Control

JG98 Related Products

Signaling Pathway

HSP (HSP90) Signaling Pathways

HSP (HSP90) Signaling Pathway

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA-MB-231 Antiproliferative assay Antiproliferative activity against human MDA-MB-231 cells by MTT assay, IC50=0.39μM. 29953808
MDA-MB-231 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay, EC50=0.4μM. 24312699
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay, EC50=0.7μM. 24312699
MCF7 Antiproliferative assay Antiproliferative activity against human MCF7 cells by MTT assay, IC50=0.71μM. 29953808
MEF Antiproliferative assay Antiproliferative activity against MEF cells by MTT assay, IC50=4.2μM. 29953808
MDA-MB-231 Autophagic assay 5 to 10 uM 24 hrs Induction of autophagic flux in human MDA-MB-231 cells assessed as increase in p62 oligomerization at 5 to 10 uM after 24 hrs 24312699
MDA-MB-231 Apoptosis assay 10 uM 48 hrs Induction of apoptosis in human MDA-MB-231 cells assessed as caspase-3 cleavage at 10 uM after 48 hrs 24312699
MCF7 Autophagic assay 5 to 10 uM 24 hrs Induction of autophagic flux in human MCF7 cells assessed as increase in p62 oligomerization at 5 to 10 uM after 24 hrs 24312699
MDA-MB-231 Apoptosis assay 10 uM 48 hrs Induction of apoptosis in human MDA-MB-231 cells assessed as PARP cleavage at 10 uM after 48 hrs 24312699
MCF7 Autophagic assay 5 to 10 uM 24 hrs Induction of autophagic flux in human MCF7 cells assessed as decrease in p62 monomer level at 5 to 10 uM after 24 hrs 24312699
MDA-MB-231 Autophagic assay 5 to 10 uM 24 hrs Induction of autophagic flux in human MDA-MB-231 cells assessed as decrease in p62 monomer level at 5 to 10 uM after 24 hrs 24312699
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Biological Activity

Description JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.
Targets
Hsp70 [1]

Chemical Information & Solubility

Molecular Weight 534.54 Formula

C24H21Cl2N3OS3
CAS No. 1456551-16-8 SDF --
Smiles CCN1C(=CC2=[N+](C=CS2)CC3=CC=CC=C3)SC(=C4N(C5=C(S4)C=C(C=C5)Cl)C)C1=O.[Cl-]
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 10 mg/mL ( (18.7 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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