Home Immunology & Inflammation PD-1/PD-L1 inhibitor GS-4224 For research use only.

GS-4224

Synonyms: Evixapodlin, PD-1/PD-L1-IN 7

GS-4224 (Evixapodlin, PD-1/PD-L1-IN 7) is an inhibitor of human PD-1/PD-L1 protein/protein interaction with an IC50 of 0.213 nM. It enhances IFN-γ and Granzyme B Production in chronic hepatitis B (CHB) CD8+ T Cells and CD4+ T Cells. It exhibits anticancer and antiviral functions.

GS-4224 Chemical Structure

GS-4224 Chemical Structure

CAS No. 2374856-75-2

Purity & Quality Control

Batch: E132201 DMSO]100 mg/mL]false]Ethanol]12 mg/mL]false]Water]Insoluble]false Purity: 99.08%
99.08

GS-4224 Related Products

Biological Activity

Description GS-4224 (Evixapodlin, PD-1/PD-L1-IN 7) is an inhibitor of human PD-1/PD-L1 protein/protein interaction with an IC50 of 0.213 nM. It enhances IFN-γ and Granzyme B Production in chronic hepatitis B (CHB) CD8+ T Cells and CD4+ T Cells. It exhibits anticancer and antiviral functions.
Targets
PD-1/PD-L1 [1]
0.213 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04049617 Terminated
Advanced Solid Tumors
Gilead Sciences
 August 26 2019 Phase 1

Chemical Information & Solubility

Molecular Weight 691.61 Formula

C34H36Cl2N8O4
CAS No. 2374856-75-2 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (144.59 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 12 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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