Home Immunology & Inflammation COX inhibitor Firocoxib (ML 1785713) For research use only.

Firocoxib (ML 1785713)

Synonyms: ML 1785713

Firocoxib (ML 1785713) is a cyclooxygenase (COX)-2 inhibitor and a nonsteroidal anti-inflammatory drug. In vitro firocoxib inhibits COX-1 and COX-2 with an IC50 of 7.5 mM and 0.13 mM respectively in feline blood.

Firocoxib (ML 1785713) Chemical Structure

Firocoxib (ML 1785713) Chemical Structure

CAS No. 189954-96-9

Purity & Quality Control

Batch: E050001 DMSO]67 mg/mL]false]Ethanol]3 mg/mL]false]Water]Insoluble]false Purity: 99.92%
99.92

Firocoxib (ML 1785713) Related Products

Signaling Pathway

COX Signaling Pathways

COX Signaling Pathway

Biological Activity

Description Firocoxib (ML 1785713) is a cyclooxygenase (COX)-2 inhibitor and a nonsteroidal anti-inflammatory drug. In vitro firocoxib inhibits COX-1 and COX-2 with an IC50 of 7.5 mM and 0.13 mM respectively in feline blood.
Targets
COX-2 [1]
(in feline blood)
130 μM
In Vivo
In vivo

Firocoxib is a potent, selective COX-2 inhibitor used in cats, which is effective in attenuating febrile responses in cats when administered 14 hours before LPS challenge.[1]
Animal Research Animal Models Domestic shorthair cats
Dosages 1, 3 mg/kg for LPS challenge study 1; 0.75, 1.5 mg/kg for LPS challenge study 2
Administration o.g.

Chemical Information & Solubility

Molecular Weight 336.4 Formula

C17H20O5S
CAS No. 189954-96-9 SDF --
Smiles CC1(C)OC(=O)C(=C1C2=CC=C(C=C2)[S](C)(=O)=O)OCC3CC3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 67 mg/mL ( (199.16 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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