Home Neuronal Signaling Dopamine Receptor agonist Fenoldopam For research use only.

Fenoldopam

Synonyms: SKF 82526

Fenoldopam (SKF 82526) is a selective dopamine-1 (DA1) receptor agonist with natriuretic/diuretic properties with EC50 of 55.5 nM in stimulating cAMP accumulation in LLC-PK1 cells, which is more potent than DA .

Fenoldopam Chemical Structure

Fenoldopam Chemical Structure

CAS No. 67227-56-9

Purity & Quality Control

Batch: S208901 DMSO]77 mg/mL]false]Water]10 mg/mL]false]Ethanol]Insoluble]false Purity: 99.70%
99.70

Fenoldopam Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description Fenoldopam (SKF 82526) is a selective dopamine-1 (DA1) receptor agonist with natriuretic/diuretic properties with EC50 of 55.5 nM in stimulating cAMP accumulation in LLC-PK1 cells, which is more potent than DA .
Targets
DA1 receptor [1]
55.5 nM(EC50)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02620761 Terminated
Patent Ductus Arteriosus (PDA)|Acute Kidney Injury (AKI)
Medical College of Wisconsin
 February 6 2019 Phase 2|Phase 3
NCT00592150 Unknown status
Hypertension
University of Virginia|National Institutes of Health (NIH)
 June 2007 Phase 1

Chemical Information & Solubility

Molecular Weight 305.76 Formula

C16H16ClNO3
CAS No. 67227-56-9 SDF Download Fenoldopam SDF
Smiles OC1=CC=C(C=C1)C2CNCCC3=C(Cl)C(=C(O)C=C23)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 77 mg/mL ( (251.83 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 10 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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