Decursinol angelate

Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.

Decursinol angelate Chemical Structure

Decursinol angelate Chemical Structure

CAS No. 130848-06-5

Purity & Quality Control

Batch: S381901 DMSO]65 mg/mL]false]]]false]]]false Purity: 99.62%
99.62

Decursinol angelate Related Products

Signaling Pathway

Biological Activity

Description Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.
Targets
PKC [2]
In vitro
In vitro Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB. Decursinol angelate also inhibits PGE2-induced expression of cyclooxygenase-2 and the activation of the Ras/Raf/Erk pathway, which activates downstream targets for cell survival. Decursinol angelate greatly reduces the PGE2-induced activation of NF-κB p50 and p65 subunits. It has been reported to suppress the growth of estrogen-stimulated and estrogen-independent growth and survival of breast cancer MCF-7 and MDA-MB-231 cells. Decursinol angelate also suppresses the growth of cancer cells through the inhibition of phosphatidylinositol 3'-kinase (PI3K)/Akt, extracellular-signal-regulated kinase (Erk) and nuclear factor-κB (NFκB). Decursinol angelate has anti-leukemic activity through the suppression of protein kinase C activation in human leukemia cells[1].
Cell Research Cell lines MCF-7 cells
Concentrations 10 μM, 20 μM, 50 μM
Incubation Time 24 hours
Method

Cells are treated with decursinol angelate at different exposure concentrations (10 μM, 20 μM, 50 μM) for 24 hours in complete medium.

In Vivo
In vivo Decursinol angelate has anti-angiogenic activity both in vitro and in vivo[1].
Animal Research Animal Models Jugular vein cannulated CD male rats
Dosages 50 mg/kg
Administration oral

Chemical Information & Solubility

Molecular Weight 328.36 Formula

C19H20O5

CAS No. 130848-06-5 SDF Download Decursinol angelate SDF
Smiles CC=C(C)C(=O)OC1CC2=C(C=C3C(=C2)C=CC(=O)O3)OC1(C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 65 mg/mL ( (197.95 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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