Home TGF-beta/Smad PKC inhibitor Myricitrin For research use only.

Myricitrin

Synonyms: Myricitrine

Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effects.

Myricitrin Chemical Structure

Myricitrin Chemical Structure

CAS No. 17912-87-7

Purity & Quality Control

Batch: S232701 DMSO]93 mg/mL]false]Ethanol]1 mg/mL]false]Water]Insoluble]false Purity: 99.77%
99.77

Myricitrin Related Products

Signaling Pathway

PKC Signaling Pathways

PKC Signaling Pathway

Biological Activity

Description Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effects.
Targets
PKCα [1] PKCε [1]
In vitro
In vitro Myricitrin, a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effect. Myricitrin produces pronounced antinociception against chemical and mechanical models of pain in rodents via preventing the protein kinase C (PKC) alpha and PKC epsilon activation by phorbol myristate acetate (PMA). [1] Another study proves that opening of voltage- and small-conductance calcium-gated K(+) channels and reduction of calcium influx leads to the antinociceptive of myricitrin. [2] Myricitrin also decreases H2O2-induced apoptosis in vascular endothelial cells via inhibition of p53 gene expression, activation of caspase-3 and the MAPK signaling pathway, and alteration of the patterns of pro-apoptotic and anti-apoptotic gene expression. [3]
In Vivo
In vivo In mice, myricitrin (i.p. 10 mg/kg or 30 mg/kg) blocks apomorphine-induced stereotypy and climbing, and increases hindlimb retraction time (HRT).[4]
Animal Research Animal Models male adult Swiss albino mice
Dosages 10 mg/kg or 30 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 464.38 Formula

C21H20O12
CAS No. 17912-87-7 SDF Download Myricitrin SDF
Smiles CC1C(C(C(C(O1)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C(=C4)O)O)O)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 93 mg/mL ( (200.26 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 1 mg/mL

Water : Insoluble


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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