Chebulagic acid

Chebulagic acid, isolated form Terminalia chebula Retz, is a reversible and non-competitive inhibitor of maltase with a Ki value of 6.6 μM. Chebulagic acid shows potent anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. Chebulagic acid also shows potent COX–LOX dual inhibition activity with IC50 values of 15 μM, 0.92 μM and 2.1 μM for COX-1, COX-2 and 5-LOX respectively.

Chebulagic acid Chemical Structure

Chebulagic acid Chemical Structure

CAS No. 23094-71-5

Purity & Quality Control

Batch: E022601 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.88%
99.88

Chebulagic acid Related Products

Signaling Pathway

Biological Activity

Description

Chebulagic acid, isolated form Terminalia chebula Retz, is a reversible and non-competitive inhibitor of maltase with a Ki value of 6.6 μM. Chebulagic acid shows potent anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. Chebulagic acid also shows potent COX–LOX dual inhibition activity with IC50 values of 15 μM, 0.92 μM and 2.1 μM for COX-1, COX-2 and 5-LOX respectively.

Targets
COX-2 [3] 5-LOX [3] maltase [1] COX-1 [3]
0.92 μM 2.1 μM 6.6 μM(Ki) 15 μM

Chemical Information & Solubility

Molecular Weight 954.66 Formula

C20H28O4

CAS No. 23094-71-5 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
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DMSO : 100 mg/mL ( (104.74 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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