Home Metabolism Phospholipase (e.g. PLA) inhibitor Cambinol For research use only.

Cambinol

Cambinol is a novel uncompetitive nSMase2 inhibitor with a K i value of 7 μM (IC50 = 5 ± 1 μM).

Cambinol Chemical Structure

Cambinol Chemical Structure

CAS No. 14513-15-6

Purity & Quality Control

Batch: S591301 DMSO]21 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.73%
99.73

Cambinol Related Products

Signaling Pathway

Phospholipase (e.g. PLA) Signaling Pathways

Phospholipase (e.g. PLA) Signaling Pathway

Biological Activity

Description Cambinol is a novel uncompetitive nSMase2 inhibitor with a K i value of 7 μM (IC50 = 5 ± 1 μM).
Targets
nSMase2 [1]
(Cell-free assay)
7 μM(Ki)
In vitro
In vitro Cambinol decreases tumor necrosis factor-α or interleukin-1 β-induced increases of ceramide and cell death in primary neurons. Cambinol is an inhibitor of the NAD-dependent deacetylase activity of sirtuin, human silent information regulator type 1/2 (SIRT1/2), with IC50 values of 56 μM and 59 μM for SIRT1 and SIRT2, respectively. Cambinol induces apoptosis in BCL6-expressing Burkitt lymphoma cell lines. Cambinol is approximately a 10-fold more potent human nSMase2 inhibitor compared to SIRT1/2[1]. Cambinol is a potent inhibitor of acidic pHe-mediated anterograde lysosome trafficking[2].
Cell Research Cell lines DU145 cells
Concentrations 50 μM
Incubation Time 2 h
Method

--
In Vivo
In vivo Cambinol is well tolerated in mice and has potent antitumor activity in vivo[2].

Chemical Information & Solubility

Molecular Weight 360.43 Formula

C21H16N2O2S
CAS No. 14513-15-6 SDF --
Smiles C1=CC=C(C=C1)C2=C(C(=O)NC(=S)N2)CC3=C(C=CC4=CC=CC=C43)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 21 mg/mL ( (58.26 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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