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Technical Data
| Formula | C21H16N2O2S |
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| Molecular Weight | 360.43 | CAS No. | 14513-15-6 | |
| Solubility (25°C)* | In vitro | DMSO | 21 mg/mL (58.26 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Cambinol is a novel uncompetitive nSMase2 inhibitor with a K i value of 7 μM (IC50 = 5 ± 1 μM). | ||
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| Targets |
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| In vitro | Cambinol decreases tumor necrosis factor-α or interleukin-1 β-induced increases of ceramide and cell death in primary neurons. Cambinol is an inhibitor of the NAD-dependent deacetylase activity of sirtuin, human silent information regulator type 1/2 (SIRT1/2), with IC50 values of 56 μM and 59 μM for SIRT1 and SIRT2, respectively. Cambinol induces apoptosis in BCL6-expressing Burkitt lymphoma cell lines. Cambinol is approximately a 10-fold more potent human nSMase2 inhibitor compared to SIRT1/2[1]. Cambinol is a potent inhibitor of acidic pHe-mediated anterograde lysosome trafficking[2]. | ||
| In vivo | Cambinol is well tolerated in mice and has potent antitumor activity in vivo[2]. |
Protocol (from reference)
| Cell Assay: |
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References
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.