Home Metabolism Phospholipase (e.g. PLA) inhibitor Quinacrine 2HCl For research use only.

Quinacrine 2HCl

Synonyms: Quinacrine dihydrochloride

Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.

Quinacrine 2HCl Chemical Structure

Quinacrine 2HCl Chemical Structure

CAS No. 69-05-6

Purity & Quality Control

Batch: S425501 Water]41 mg/mL]false]Ethanol]28 mg/mL]false]DMSO]14 mg/mL]false Purity: 99.01%
99.01

Quinacrine 2HCl Related Products

Signaling Pathway

Phospholipase (e.g. PLA) Signaling Pathways

Phospholipase (e.g. PLA) Signaling Pathway

Biological Activity

Description Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.
Targets
PLA2 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00417274 Completed
Prostatic Cancer
Cleveland BioLabs
 December 2006 Phase 2

Chemical Information & Solubility

Molecular Weight 472.88 Formula

C23H30ClN3O.2HCl
CAS No. 69-05-6 SDF Download Quinacrine 2HCl SDF
Smiles CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC.Cl.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 41 mg/mL

Ethanol : 28 mg/mL

DMSO : 14 mg/mL ( (29.6 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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