Home Neuronal Signaling Dopamine Receptor agonist Cabergoline For research use only.

Cabergoline

Synonyms: FCE-21336

Cabergoline (FCE-21336), an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor.

Cabergoline Chemical Structure

Cabergoline Chemical Structure

CAS No. 81409-90-7

Purity & Quality Control

Cabergoline Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description Cabergoline (FCE-21336), an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor.
Targets
D2 receptor [1] 5-HT2 [1] 5-HT2B [1] D3 receptor [1] D4 receptor [1]
0.7 nM 1.2 nM 1.2 nM 1.5 nM 9 nM
In vitro
In vitro Cabergoline prevents the oxidative stress-induced cell death of cultured cortical neurons via a D2 receptor-mediated mechanism. Cabergoline suppresses the activation of ERK signaling, which might have a role in the neuroprotection. Cabergoline significantly represses extracellular glutamate accumulation triggered by oxidative stress, and increases the expression of glutamate transporters including EAAC1, which is known to be involved in the clearance of extracellular glutamate[1].
In Vivo
In vivo Cabergoline has a long elimination half-life (63 to 109 h). An in vivo study of neuronal damage induced by intracerebroventricular (icv) injection of 6-OHDA, a neurotoxic compound that selectively damages dopaminergic neurons in male ICR mice, demonstrates that intraperitoneal (ip) administration of cabergoline for 7 days prevented nigrostriatal region dopaminergic neurons from cell death. Cabergoline also protects SH-SY5Y neuroblastoma from cell death by oxygen-glucose deprivation even when cabergoline is administered after the induction of cell death. Cabergoline increases hippocampal brain-derived neurotrophic factor (BDNF, an important regulator in the synaptic plasticity) and exerts an antidepressant effect in rats[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03965572 Unknown status
Lactation Suppressed|Cabergoline Adverse Reaction|Postpartum DVT|Postpartum Depression
Laniado Hospital
 June 7 2019 --
NCT03457389 Recruiting
Pituitary Adenoma|Prolactinoma|Pituitary Tumor|Recurrence Tumor
Seoul National University Hospital
 February 22 2018 Not Applicable
NCT01651364 Completed
Cocaine Dependence|Cocaine Abuse|Cocaine Addiction|Substance Abuse
Baylor College of Medicine|National Institute on Drug Abuse (NIDA)
 July 2011 Phase 1
NCT01270711 Completed
Parkinson''s Disease|Hyperprolactinemia
Pfizer
 November 2010 --
NCT01009567 Completed
Ovarian Hyperstimulation Syndrome
Royan Institute
 June 2009 Phase 1|Phase 2
NCT00153972 Completed
Parkinson''s Disease
Technische Universität Dresden|Pfizer
 February 2005 Phase 4

Chemical Information & Solubility

Molecular Weight 451.60 Formula

C26H37N5O2
CAS No. 81409-90-7 SDF --
Smiles CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 90 mg/mL ( (199.29 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 90 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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