Home Autophagy Autophagy activator CA77.1 For research use only.

CA77.1

Synonyms: CA

CA77.1 (CA) is a potent, brain-penetrant and orally active activator of chaperone-mediated autophagy (CMA) for the treament of Alzheimer's disease (AD).

CA77.1 Chemical Structure

CA77.1 Chemical Structure

CAS No. 2412270-22-3

Purity & Quality Control

CA77.1 Related Products

Signaling Pathway

Autophagy Signaling Pathways

Autophagy Signaling Pathway

Biological Activity

Description CA77.1 (CA) is a potent, brain-penetrant and orally active activator of chaperone-mediated autophagy (CMA) for the treament of Alzheimer's disease (AD).
Targets
CMA [1]
In Vivo
In vivo

CA77.1 activates CMA in vitro in dose- and time-dependent manner without affecting macroautophagy and when administering in vivo demonstrate brain penetrance with favorable pharmacokinetics, activation of CMA in brain of KFERQ-Dendra mice, and absence of blood or major organs toxicity after 3 months of daily treatment.[2]
Animal Research Animal Models Male wild-type mice (C57BL/6J)
Dosages 10 mg/Kg or 1mg/Kg
Administration i.v.&p.o.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01199250 Not yet recruiting
Lynch Syndrome|Recurrent Uterine Corpus Carcinoma|Stage I Uterine Corpus Cancer|Stage II Uterine Corpus Cancer|Stage III Uterine Corpus Cancer|Stage IV Uterine Corpus Cancer
Gynecologic Oncology Group|National Cancer Institute (NCI)|GOG Foundation
 January 2100 --
NCT01164735 Not yet recruiting
Recurrent Uterine Corpus Carcinoma|Stage III Uterine Corpus Cancer|Stage IV Uterine Corpus Cancer
Gynecologic Oncology Group|National Cancer Institute (NCI)|GOG Foundation
 January 2100 --
NCT06356558 Not yet recruiting
Surgery|Health Knowledge Attitudes Practice|Colorectal Disorders
University of Alabama at Birmingham|National Cancer Institute (NCI)
 May 2026 Not Applicable
NCT06353282 Not yet recruiting
PTSD Post Traumatic Stress Disorder|Adolescents|Psychotherapy
University of California Los Angeles
 July 1 2025 Phase 2

Chemical Information & Solubility

Molecular Weight 297.74 Formula

C16H12ClN3O
CAS No. 2412270-22-3 SDF --
Smiles CC(=O)NC1=CC=C(C=C1)C2=NC3=CC=C(Cl)C=C3N=C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 30 mg/mL ( (100.75 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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