Home Neuronal Signaling Dopamine Receptor agonist Bromocriptine Mesylate For research use only.

Bromocriptine Mesylate

Bromocriptine mesylate is a dopamine receptor agonist with a Ki of 12.2 nM for D3 receptor and D2 receptor and a Ki of 1659 nM, 59.7 nM, 1691 nM for D1 receptor, D4 receptor, and D5 receptor, respectively. Bromocriptine mesylate is used in the treatment of Parkinson's disease, hyperprolactinemia-associated dysfunctions, and acromegaly.

Bromocriptine Mesylate Chemical Structure

Bromocriptine Mesylate Chemical Structure

CAS No. 22260-51-1

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Bromocriptine Mesylate Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description Bromocriptine mesylate is a dopamine receptor agonist with a Ki of 12.2 nM for D3 receptor and D2 receptor and a Ki of 1659 nM, 59.7 nM, 1691 nM for D1 receptor, D4 receptor, and D5 receptor, respectively. Bromocriptine mesylate is used in the treatment of Parkinson's disease, hyperprolactinemia-associated dysfunctions, and acromegaly.
Targets
D2 receptor [1] D3 receptor [1] D4 receptor [1] D1 receptor [1] D5 receptor [1]
12.2 nM(Ki) 12.2 nM(Ki) 59.7 nM(Ki) 1659 nM(Ki) 1691 nM(Ki)
In vitro
In vitro

Bromocriptine dose-dependently reduces the number of OH radicals. [1] Bromocriptine has a strong scavenging effect on the 5,5-dimethyl-1-pyrroline-N-oxide hydroxide signal produced from Fenton's reaction. Bromocriptine also attenuates the stable free radical diphenyl-p-picrylhydrazyl signal. [2]
In Vivo
In vivo

Bromocriptine (5 mg/kg, i.p., 7 days) completely protects against the decrease in mouse striatal dopamine and its metabolites induced by intraventricular injection of 6-hydroxydopamine after intraperitoneal administration of desipramine. [1] Bromocriptine (2.5 mg/kg, i.p., daily for 3 days) significantly reduces autooxidation of brain homogenates collected from rats. [2] Bromocriptine (12.5 mg/kg) produces mild dyskinesia over the course of the study that is significantly less severe than in the L-dopa-treated group in the MPTP-treated marmoset. Bromocriptine, has a lesser tendency than L-dopa to produce dyskinesia while similarly improving motor performance in drug-naive MPTP-treated marmosets. [3] Bromocriptine (10 μM and 10 mg/kg i.p.) blocks .OH formation caused by MPTP in vitro (20 μM) and in vivo (30 mg/kg i.p.) in mice. Bromocriptine reduces an MPTP-induced increase in the activity of catalase and superoxide dismutase in substantia nigra on the seventh day. Bromocriptine blocks MPTP-induced behavioral dysfunction as well as glutathione and dopamine depletion, indicating its potent neuroprotective action. [4]

Chemical Information & Solubility

Molecular Weight 750.7 Formula

C32H40BrN5O5.CH4O3S
CAS No. 22260-51-1 SDF Download Bromocriptine Mesylate SDF
Smiles CC(C)CC1N2C(=O)C(NC(=O)C3CN(C)C4CC5=C(Br)[NH]C6=C5C(=CC=C6)C4=C3)(OC2(O)C7CCCN7C1=O)C(C)C.C[S](O)(=O)=O
Storage (From the date of receipt) 3 years -20°C powder

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