Home Metabolism Casein Kinase chemical BMS-986397 For research use only.

BMS-986397

Synonyms: CC-91633

BMS-986397 (CC-91633) is a potent and selective thalidomide-derived molecular glue degrader of CK1α and a modulator of CRBN E3 ubiquitin ligase. As a first-in-class CELMoD agent, it exhibits strong anti-leukemic activity in AML (Acute Myeloid Leukemia) and HR-MDS (High-Risk Myelodysplastic Syndrome) models, with enhanced efficacy and potency for hematologic malignancies and immunomodulation.

BMS-986397 Chemical Structure

BMS-986397 Chemical Structure

CAS No. 2564486-44-6

Purity & Quality Control

Batch: E472501 DMSO]96 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 97.95%
97.95

BMS-986397 Related Products

Biological Activity

Description BMS-986397 (CC-91633) is a potent and selective thalidomide-derived molecular glue degrader of CK1α and a modulator of CRBN E3 ubiquitin ligase. As a first-in-class CELMoD agent, it exhibits strong anti-leukemic activity in AML (Acute Myeloid Leukemia) and HR-MDS (High-Risk Myelodysplastic Syndrome) models, with enhanced efficacy and potency for hematologic malignancies and immunomodulation.

Chemical Information & Solubility

Molecular Weight 480.83 Formula

C21H16ClF3N4O4
CAS No. 2564486-44-6 SDF Download BMS-986397 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 96 mg/mL ( (199.65 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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