Home Metabolism Casein Kinase inhibitor IC261 For research use only.

IC261

Synonyms: SU-5607

IC261 (SU-5607) is a novel inhibitor of CK1. The IC50 of IC261 for CK1 is 16 μM and for Cdk5 is 4.5 mM.

IC261 Chemical Structure

IC261 Chemical Structure

CAS No. 186611-52-9

Purity & Quality Control

Batch: S823701 DMSO]62 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.75%
99.75

IC261 Related Products

Biological Activity

Description IC261 (SU-5607) is a novel inhibitor of CK1. The IC50 of IC261 for CK1 is 16 μM and for Cdk5 is 4.5 mM.
Targets
CK1 [4]
16 μM
In vitro
In vitro IC261 leads to a p53-dependent arrest of the cells with a DNA content of 4 N. It can produce effects on cell cycle progression that are indistinguishable from an established spindle poison and are dependent on the p53 status of the cells[1].
Cell Research Cell lines MEFs
Concentrations 1 μM
Incubation Time 12 h, 24 h, 48 h
Method

Cultures of MEFs of di€erent genotypes (p53+/+, p53+/-, p53-/-) are treated with the inhibitor IC261 in the low micromolar range (1 μM). After 12, 24, 48 hours exposure, the effects of IC261 on cell cycle distribution are measured by flow cytometry.
In Vivo
In vivo Intrathecal injection of a CK1 inhibitor IC261 attenuates neuropathic pain behaviors. CK1 inhibitors are found to be effective in reducing spinal excitatory response elicited by the presynaptic electrical stimulation only in neuropathic mice[2]. Targeting CK1 isoforms by IC261 influences both pancreatic tumour cell growth and apoptosis sensitivity in vitro and the growth of induced tumours in vivo[3].
Animal Research Animal Models Male C57BL/6J mice
Dosages 0.1-1 nmol
Administration intrathecal administration

Chemical Information & Solubility

Molecular Weight 311.33 Formula

C18H17NO4
CAS No. 186611-52-9 SDF Download IC261 SDF
Smiles COC1=CC(=C(C(=C1)OC)C=C2C3=CC=CC=C3NC2=O)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 62 mg/mL ( (199.14 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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