Anti-GD2 (EMD 273063)

Synonyms: null

Catalog No.A2916 Purity:≥99%

Anti-GD2 (EMD 273063) is a humanized immunoglobulin G1 (IgG1) anti-GD2 monoclonal antibody directed against the human pro-inflammatory cytokine interleukin (IL)-2 with potential antineoplastic and immunomodulatory activities. MW: 144.84 KD.

Purity & Quality Control

≥99

Choose Selective Interleukins Inhibitors

Name	Citation	IL-6	IL-1	IL-8	IL-12	IL-10	IL-13	IL-2	Others
SKF-86002	0		++
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A-740003	2		++						rat P2X7 receptor,human P2X7 receptor
Apilimod mesylate	3				++++				PIKfyve
MD2-TLR4-IN-1	0	++							TLR4,TNF-α
Danirixin (GSK1325756)	2			++					CXCR2
Resatorvid (TAK-242)	50	++++							TLR4,NO,TNF-α
Apilimod	14				++++				PIKfyve
LMT-28	✔
Atractylodin	✔							NAAA
Triolein	✔							ROS,MMP-1
Ac-YVAD-cmk		✔
Diethyl phosphate	✔
RCM-1						✔		STAT6,FOXM1,β-catenin
Stylopine		✔						COX-2,TNF-α,NO
Myrislignan	✔							NF-κB,COX-2,iNOS
NE 52-QQ57		✔						iNOS,TNF-α,PGE2
PKR-IN-C16		✔						PKR
Falcarindiol	✔							STAT,ERK,JNK
Gardenoside		✔						P2X7 Receptor,P2X3 receptor,NF-κB
T-5224		✔						c-Jun,c-Fos/AP-1,Adamts-5
IQ 3	✔							TNF-α,JNK3,JNK1
Isuzinaxib (APX-115 free base)	✔							TNFα,MCP-1/CCL2,NOX2
AUDA		✔						p38,Smad3,TGF-β
SAR-20347				✔				IFN-α,TYK2,JAK1
SU 5201							✔
Madecassic acid		✔						TNF-α,COX-2,iNOS
Homoplantaginin	✔							NF-κB,IKKβ,TNF-α
2',5'-Dihydroxyacetophenone	✔							NF-κB,ERK1/2,iNOS
Forsythoside B	✔							NF-κB,TNF-alpha,IκB
Mulberroside A		✔						NF-κB,Caspase-1,NALP3
Chelidonic acid	✔							glutamate decarboxylase,Caspase-1,NF-κB
4-Methylesculetin	✔							MPO
Muscone		✔						TNF-α,NLRP3 inflammasome,NF-κB
Ossirene (AS101)		✔
Methylthiouracil	✔							ERK1/2,NF-κB,TNF-α

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Anti-GD2 (EMD 273063) is a humanized immunoglobulin G1 (IgG1) anti-GD2 monoclonal antibody directed against the human pro-inflammatory cytokine interleukin (IL)-2 with potential antineoplastic and immunomodulatory activities. MW: 144.84 KD.

References
[1] Daniels TR, et al. Cancer Immunol Immunother. 2012;61(9):1535-1546.

References

[1] Daniels TR, et al. Cancer Immunol Immunother. 2012;61(9):1535-1546.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

Molecular Weight	144.84
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100mMPro-Ac,20mMArg-Ac，pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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