Andecaliximab (Anti-MMP9)

Synonyms: null

Catalog No.A2399 Purity:99%

Andecaliximab (Anti-MMP9) is a recombinant chimeric IgG4 monoclonal antibody (mAb) that targets matrix metalloproteinase 9 (MMP9). Andecaliximab shows antifibrotic efficacy in idiopathic pulmonary fibrosis mouse models. MW: 145.5 kD.

Purity & Quality Control

Batch: Purity: 99% Protein concentration: 4.998mg/ml Endotoxin Level: ＜1EU/mg

Choose Selective MMP Inhibitors

Name	Citation	MMP	MMP1	MMP2	MMP3	MMP7	MMP8	MMP9	MMP12	MMP13	MMP14	MMP26
Batimastat (BB-94)	34		+++	+++	+	++		+++
Ilomastat (GM6001)	56		++++	+++		+++	++++	++++	+++			++++
ARP 100	0			++
MMP-9-IN-1	7							+
T-26c	0	++++								++++
SB-3CT	29			+				+
Marimastat (BB-2516)	19		++	++	+	+		+++			++
NSC 405020	✔
SM-7368							✔
CL-82198	✔
Triolein		✔										ROS,IL-6
Solasodine			✔									miR-21,RECK,EMMPRIN
Isoliquiritin apioside	✔											NF-κB,MAPK
T-5224				✔								Adamts-5,IL-1β,c-Jun
AUDA							✔					TNF-α,IL-1β,p38
o-Phenanthroline				✔								Fe2+,Collagenase
Trans-Zeatin		✔										JNK,ERK,p38 MAPK
TAPI-1	✔											ADAM17/TACE
Nobiletin	✔

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Andecaliximab (Anti-MMP9) is a recombinant chimeric IgG4 monoclonal antibody (mAb) that targets matrix metalloproteinase 9 (MMP9). Andecaliximab shows antifibrotic efficacy in idiopathic pulmonary fibrosis mouse models. MW: 145.5 kD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1518996-49-0
Molecular Weight	145.5 kDa
Isotype	Human IgG4SP
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100mMPro-Ac,20mMArg-Ac，pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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