Home Transmembrane Transporters Potassium Channel inhibitor - Autophagy activator Amiodarone HCl For research use only.

Amiodarone HCl

Synonyms: NSC 85442

Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.

Amiodarone HCl Chemical Structure

Amiodarone HCl Chemical Structure

CAS No. 19774-82-4

Purity & Quality Control

Amiodarone HCl Related Products

Signaling Pathway

Potassium Channel Signaling Pathways

Potassium Channel Signaling Pathway

Biological Activity

Description Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.
Targets
Potassium channel [1]
In vitro
In vitro

Amiodarone possesses an inhibitory effect on the fast sodium channel as well as on the slow calcium channel. Amiodarone also has non-competitive antisympathetic effects, and modulates thyroid function and phospholipid metabolism. Amiodarone penetrates deeply into the lipid matrix of the membrane, and is released from cardiac tissues very slowly when washed out. Amiodarone (44–88 μM) depresses Vmax of guinea pig papillary muscle without affecting the resting membrane potential, and that this Vmax inhibition is enhanced in a frequency- or use-dependent manner like Class I antiarrhythmic drugs. Amiodarone (50–88 μM) is also found to suppress the depolarization-induced spontaneous action potentials (abnormal automaticity) in ventricular muscles and in Purkinje fibers. [1]
In Vivo
In vivo

Amiodarone (1.25–25 mg/kg) results in a decrease in sinus rate, a prolongation of effective and functional refractory periods of the atrioventricular node, and a frequency-dependent conduction delay in the atrioventricular node and in the ventricle of anesthetized dogs. Amiodarone (50 mg/kg/day, i.p. for 3–4 weeks) results in significant decreases in the current density of iK and ito in ventricular cells without affecting iCa and iK1 densities in rabbit. Amiodarone (AM) inhibits intracellular conversion from thyroxine (T4) to triiodothyronine (T3) via 5′-deiodination (5′DI) without affecting intracellular conversion from T4 to reverse T3 (rT3). [1]
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NCT06067438 Not yet recruiting
Atrial Fibrillation|Esophageal Carcinoma
OHSU Knight Cancer Institute
 May 1 2024 Phase 2
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Population Health Research Institute
 May 31 2024 Phase 3
NCT05852704 Recruiting
Chronic Coronary Syndrome|Atrial Fibrillation
Region Örebro County|Odense University Hospital|Aarhus University Hospital|Örebro University Sweden|Sahlgrenska University Hospital Sweden|Göteborg University|University of Leeds|Skane University Hospital|London School of Hygiene and Tropical Medicine|St. Anne''s University Hospital Brno Czech Republic|Mount Sinai Hospital New York|University Hospital Linkoeping|Icahn School of Medicine at Mount Sinai
 April 4 2024 Phase 3
NCT05543278 Not yet recruiting
Surgery Cardiac|Atrial Fibrillation
Massachusetts General Hospital
 February 1 2024 Phase 4

Chemical Information & Solubility

Molecular Weight 681.77 Formula

C25H29I2NO3.HCl
CAS No. 19774-82-4 SDF Download Amiodarone HCl SDF
Smiles CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (146.67 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble


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In vivo
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