Home Transmembrane Transporters Potassium Channel inhibitor Sophocarpine For research use only.

Sophocarpine

Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.

Sophocarpine Chemical Structure

Sophocarpine Chemical Structure

CAS No. 6483-15-4

Purity & Quality Control

Sophocarpine Related Products

Signaling Pathway

Potassium Channel Signaling Pathways

Potassium Channel Signaling Pathway

Biological Activity

Description Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
In vitro
In vitro Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. [1] Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. [2] In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM. [3]
In Vivo
In vivo Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice. [1] LD50: Mice 63.94mg/kg (i.v.) [4]

Chemical Information & Solubility

Molecular Weight 246.35 Formula

C15H22N2O
CAS No. 6483-15-4 SDF Download Sophocarpine SDF
Smiles C1CC2CN3C(CC=CC3=O)C4C2N(C1)CCC4
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 49 mg/mL ( (198.9 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 49 mg/mL

Water : 6 mg/mL


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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