Home Transmembrane Transporters Potassium Channel antagonist PAP-1 For research use only.

PAP-1

Synonyms: 5-(4-Phenoxybutoxy)psoralen

PAP-1 (5-(4-phenoxybutoxy)psoralen), a Kv1.3 antagonist with an EC50 of 2 nM, inhibits the proliferation of human T cells and suppresses delayed type hypersensitivity in rats.

PAP-1 Chemical Structure

PAP-1 Chemical Structure

CAS No. 870653-45-5

Purity & Quality Control

Batch: E037801 DMSO]70 mg/mL]false]Ethanol]25 mg/mL]false]Water]Insoluble]false Purity: 99.84%
99.84

PAP-1 Related Products

Signaling Pathway

Potassium Channel Signaling Pathways

Potassium Channel Signaling Pathway

Biological Activity

Description PAP-1 (5-(4-phenoxybutoxy)psoralen), a Kv1.3 antagonist with an EC50 of 2 nM, inhibits the proliferation of human T cells and suppresses delayed type hypersensitivity in rats.
Targets
Kv1.3 [1]
2 nM(EC50)
In vitro
In vitro

PAP-1 (2-100 nM; 30 minutes) suppresses the proliferation of CCR7-TEM cells with IC50 of 10 nM.[1]
Cell Research Cell lines CCR7-TEM cells
Concentrations 2-100 nM
Incubation Time 30 min
Method

CCR7- T cells are then seeded at 5 X 104 per well together with 5 X 104 autologous irradiated peripheral blood mononuclear cells in RPMI culture medium into round-bottomed, 96-well plates. PAP-1 is added at different concentrations, and the cells are stimulated with 25 ng/ml soluble anti-CD3 Ab 30 min later. Cells are harvested onto glassfiber filters, and radioactivity is measured in a ß-scintillation counter.
In Vivo
In vivo

PAP-1 (0.3-3 mg/kg; i.p.; three times daily for 48 hours) prevents delayed type hypersensitivity (DTH) in lewis rats.[1]

Chemical Information & Solubility

Molecular Weight 350.37 Formula

C21H18O5
CAS No. 870653-45-5 SDF --
Smiles O=C1OC2=CC3=C(C=CO3)C(=C2C=C1)OCCCCOC4=CC=CC=C4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 70 mg/mL ( (199.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 25 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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