Home Neuronal Signaling Dopamine Receptor antagonist Alizapride HCl For research use only.

Alizapride HCl

Synonyms: Alizapride hydrochloride

Alizapride HCl(Alizapride hydrochloride) is a dopamine receptor antagonist used for the theropy of nausea and vomiting.

Alizapride HCl Chemical Structure

Alizapride HCl Chemical Structure

CAS No. 59338-87-3

Purity & Quality Control

Batch: S425701 Water]70 mg/mL]false]DMSO]42 mg/mL]false]Ethanol]Insoluble]false Purity: 99.08%
99.08

Alizapride HCl Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description Alizapride HCl(Alizapride hydrochloride) is a dopamine receptor antagonist used for the theropy of nausea and vomiting.
Targets
Dopamine receptor [1]
In vitro
In vitro

Alizapride has a N-allyl moiety which potentially could undergo N-deallylation and/or epoxidation reactions, the formation of chemically reactive metabolites can be expected. [1]
In Vivo
In vivo

Alizapride demonstrates little toxicity (particularly after parenteral administration) in mice and rats. Alizapride is mainly excreted as unmodified drug after oral or parenteral administration; however, a share of about 25% undergoes metabolic transformation before deletion. [1] Alizapride (5 mg/kg, s.c.) antagonizes the decrease in gastrointestinal transit induced by the above doses of Apomorphine in the rat. [2]

Chemical Information & Solubility

Molecular Weight 351.83 Formula

C16H21N5O2.HCl
CAS No. 59338-87-3 SDF Download Alizapride HCl SDF
Smiles COC1=CC2=C(C=C1C(=O)NCC3CCCN3CC=C)NN=N2.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 70 mg/mL

DMSO : 42 mg/mL ( (119.37 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Alizapride HCl | Alizapride HCl ic50 | Alizapride HCl price | Alizapride HCl cost | Alizapride HCl solubility dmso | Alizapride HCl purchase | Alizapride HCl manufacturer | Alizapride HCl research buy | Alizapride HCl order | Alizapride HCl mouse | Alizapride HCl chemical structure | Alizapride HCl mw | Alizapride HCl molecular weight | Alizapride HCl datasheet | Alizapride HCl supplier | Alizapride HCl in vitro | Alizapride HCl cell line | Alizapride HCl concentration | Alizapride HCl nmr