Home Cytoskeletal Signaling Microtubule Associated inhibitor Nab-Paclitaxel For research use only.

Nab-Paclitaxel

Nab-Paclitaxel, a novel solvent-free taxane with the binding ratio of human serum albumin to Paclitaxel of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system. Solutions are unstable and should be fresh-prepared.

Nab-Paclitaxel Chemical Structure

Nab-Paclitaxel Chemical Structure

CAS No.

Purity & Quality Control

Nab-Paclitaxel Related Products

Signaling Pathway

Microtubule Associated Signaling Pathways

Microtubule Associated Signaling Pathway

Biological Activity

Description Nab-Paclitaxel, a novel solvent-free taxane with the binding ratio of human serum albumin to Paclitaxel of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system. Solutions are unstable and should be fresh-prepared.
In vitro
In vitro

Treating human pancreatic ductal adenocarcinoma cells first with gemcitabine followed by Nab-Paclitaxel at 48 hours is found to have the greatest inhibition of cell growth.[3]
Cell Research Cell lines Human pancreatic ductal adenocarcinoma cell lines
Concentrations 100 nM
Incubation Time 24 h
Method

Cells are seeded in 96-well plates at a density of 1,000–5,000 cells per well in 100 μL medium. Nab-Paclitaxel and gemcitabine are added and incubated at 37°C for 24 hours. Proliferation Is measured by the alamarBlue assay.
In Vivo
In vivo

In mice with human pancreatic cancer xenografts, nab-paclitaxel alone and in combination with gemcitabine deplete the desmoplastic stroma. The intratumoral concentration of gemcitabine is increased by 2.8-fold in mice receiving nab-paclitaxel plus gemcitabine versus those receiving gemcitabine alone.[4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04715542 Not yet recruiting
Chemotherapy Induced Peripheral Neuropathy (CIPN)
University of Bern|Insel Gruppe AG University Hospital Bern|Hospital of Thun|Tumor- und Brustzentrum ZeTuP St.Gallen|Gesundheitszentrum Fricktal AG|Kantonsspital Winterthur KSW|Kantonsspital Graubünden|Kantonsspital Aarau
 August 2024 Phase 3
NCT06199466 Recruiting
Metastatic Pancreatic Cancer
M.D. Anderson Cancer Center|280Bio Inc
 January 22 2024 Phase 1
NCT06059001 Recruiting
Metastatic Pancreatic Cancer
Peptomyc S.L.
 August 31 2023 Phase 1
NCT05982522 Not yet recruiting
Solid Tumor
InxMed (Shanghai) Co. Ltd.
 August 2023 Phase 1|Phase 2
NCT05562297 Not yet recruiting
Pancreatic Cancer Stage IB|Pancreatic Cancer Stage IIA|Pancreatic Cancer Stage IIB|Pancreatic Cancer Stage III
Shanghai Zhongshan Hospital|Fudan University
 July 1 2023 Phase 2

Chemical Information & Solubility

Molecular Weight 853.91（Only for Paclitaxel） Formula

C47H51NO14
CAS No. SDF --
Storage (From the date of receipt) Store at room temperature, 3 years Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

In vitro
Batch:

Water : 3 mg/mL

DMSO : ＜1 mg/mL ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : ＜1 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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