Home Cytoskeletal Signaling Microtubule Associated inhibitor TRx0237 (LMTX) mesylate For research use only.

TRx0237 (LMTX) mesylate

Synonyms: Hydromethylthionine mesylate

TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.

TRx0237 (LMTX) mesylate Chemical Structure

TRx0237 (LMTX) mesylate Chemical Structure

CAS No. 1236208-20-0

Purity & Quality Control

TRx0237 (LMTX) mesylate Related Products

Signaling Pathway

Microtubule Associated Signaling Pathways

Microtubule Associated Signaling Pathway

Biological Activity

Description TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
Targets
tau protein aggregation [1]
In vitro
In vitro TRx 0237 (LMTX™) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. It is a purified forms of Methylene Blue, an old drug that predates the FDA and is being widely used in Africa for the treatment for malaria as well as for methemoglobinemia and other conditions[2]. An in vitro study showed the ability of TRx 0237 in disrupting PHFs(paired helical filaments) isolated from Alzheimer's Disease brain tissues at the concentration at 0.16 μM[1].
In Vivo
In vivo TRx 0237 dose-dependently rescues the learning impairment and restores behavioral flexibility in a spatial problem-solving water-maze task in L1 (minimum effective dose: 9 mg MT/kg for TRx0237) and correctes motor learning in L66 (effective doses: 4 mg MT/kg). It reduces the number of tau-reactive neurons, particularly in the hippocampus and entorhinal cortex in L1 and in a more widespread manner in L66[1].

Chemical Information & Solubility

Molecular Weight 477.62 Formula

C16H19N3S.2CH4O3S
CAS No. 1236208-20-0 SDF Download TRx0237 (LMTX) mesylate SDF
Smiles CN(C)C1=CC2=C(C=C1)NC3=C(S2)C=C(C=C3)N(C)C.CS(=O)(=O)O.CS(=O)(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 96 mg/mL ( (200.99 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 96 mg/mL

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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