Nab-Paclitaxel

Catalog No.E1068 Batch:E106802

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Technical Data

Formula

C47H51NO14
Molecular Weight 853.91（Only for Paclitaxel） CAS No.
Solubility (25°C)* In vitro Water 3 mg/mL warmed with 50ºC water bath
DMSO ＜1 mg/mL
Ethanol ＜1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Nab-Paclitaxel, a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system. Solutions are unstable and should be fresh-prepared.
In vitro

Treating human pancreatic ductal adenocarcinoma cells first with gemcitabine followed by Nab-Paclitaxel at 48 hours is found to have the greatest inhibition of cell growth.[3]
In vivo

In mice with human pancreatic cancer xenografts, nab-paclitaxel alone and in combination with gemcitabine deplete the desmoplastic stroma. The intratumoral concentration of gemcitabine is increased by 2.8-fold in mice receiving nab-paclitaxel plus gemcitabine versus those receiving gemcitabine alone.[4]

Protocol (from reference)

Cell Assay:

[3]
  • Cell lines

    Human pancreatic ductal adenocarcinoma cell lines

  • Concentrations

    100 nM

  • Incubation Time

    24 h

  • Method

    Cells are seeded in 96-well plates at a density of 1,000–5,000 cells per well in 100 μL medium. Nab-Paclitaxel and gemcitabine are added and incubated at 37°C for 24 hours. Proliferation Is measured by the alamarBlue assay.

Selleck's Nab-Paclitaxel has been cited by 1 publication

Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma [ J Transl Med, 2023, 21(1):730] PubMed: 37848935

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.