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MG132
Synonyms: (S,R,S)-(-)-MG-132, Z-Leu-D-Leu-Leu-al
MG132 ((S,R,S)-(-)-MG132, Z-Leu-D-Leu-Leu-al) is a potent proteasome (ChTL, TL, and PGPH) inhibitor. MG132 also inhibits calpain (IC50=1.2 μM).
MG132 Chemical Structure
CAS No. 1211877-36-9
Selleck's MG-132 had a noticeably greater effect when compared with similar products from Sigma: This is directly due to using the (S, R, S) - (-) - 2 configuration.
P21 protein can be degraded through ubiquitylation pathway. Inhibition of proteasome activities results in the accumulation of P21 protein, therefore, the more powerful the inhibiting effect, the more P21 protein is accumulated. (testing protein: P21; Cell line: Hela; treatment condition: final concentration of MG-132 is 5μM, with a 6 hour treatment time)
Purity & Quality Control
Batch:
Purity:
99.69%
99.69
Products often used together with MG132
Cycloheximide is a protein synthesis inhibitor. It is used in combination with MG132 to investigate whether the protein changes are due to the synthesis pathway or the proteasome degradation pathway.
Epoxomicin is a highly selective and irreversible proteasome inhibitor, which is used in conjunction with MG132 to compare the efficacy differences of different proteasome inhibitors.
Kisselev AF. Site-Specific Proteasome Inhibitors. Biomolecules. 2021 Dec 31;12(1):54.
MG132 and Cycloheximide co-treatment rescues the DM1 protein from degradation in HEK293 cells.
MG-132 and Y-27632 2HCl treatment inhibits protrusion and increases maturation-promoting factor (MPF) activities, whereas mitogen-activated protein kinase (MAPK) activity remains unchanged in oocytes.
MG132 Related Products
| Related Targets | 20S proteasome | Click to Expand |
|---|---|---|
| Related Products | Epoxomicin (BU-4061T) Celastrol Oprozomib ONX-0914 (PR-957) Delanzomib VR23 Marizomib (Salinosporamide A) PI-1840 | Click to Expand |
| Related Compound Libraries | FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Protease Inhibitor Library Ubiquitination Compound Library | Click to Expand |
Signaling Pathway
Cell Data
| Cell Lines | Assay Type | Concentration | Incubation Time | Formulation | Activity Description | PMID |
|---|---|---|---|---|---|---|
| LP-1 | Apoptosis Assay | 300 nM | 24 h | DMSO | Induces apoptosis by increasing cleaved PARP level and reducing Mcl-1 protein level | 15958589 |
| PC3 | Growth Inhibition Assay | 20 μM | 48 h | DMSO | IC50=0.6 μM | 16686537 |
| PC12 | Function Assay | 100 μM | 24 h | DMSO | Inhibits 6-OHDA- and H2O2-induced cytotoxicity | 17158454 |
| LPS-stimulated RAW264.7 cells | Function Assay | DMSO | Inhibits NF-kappaB DNA binding | 17407277 | ||
| OCI-Ly3 | Function Assay | 10 μM | 4 h | DMSO | Induces human IkappaBalpha stabilization with EC50 of 1 μM | 18024113 |
| A2780 cDDP | Apoptosis Assay | 24 h | DMSO | Induces apoptosis by inhibiting PTEN degradation | 17684018 | |
| COS-7 | Cytotoxic Assay | 10 μM | DMSO | IC50<10 μM | 18088097 | |
| HuH-7 | Cytotoxic Assay | 10 μM | DMSO | IC50<10 μM | 18088097 | |
| Hepa-1c1c7 | Function Assay | 25 μM | 6 h | DMSO | Increases Nrf2 protein level | 20392544 |
| IPC227F | Cytotoxic Assay | 1 μM | 48 h | DMSO | IC50=0.077 μM | 21924528 |
| Calu6 | Function Assay | 10 μM | 18 h | DMSO | Significantly accumulates frataxin precursor | 23506486 |
| IFN-gamma-induced RAW264.7 | Function Assay | DMSO | Inhibits nitric oxide production with IC50 of 0.077 μM | 22277277 | ||
| HEK-293 | Kinase Assay | 2 and 20 μM | 2 h | DMSO | Inhibits ChT-L activity with IC50 of 9 nM | 23540790 |
| MCF10A | Growth Inhibition Assay | 1 μM | 72 h | DMSO | IC50=0.29 μM | 24153206 |
| MCF-7 | Growth Inhibition Assay | 1 μM | 72 h | DMSO | IC50=0.13 μM | 24153206 |
| HeLa | Kinase Assay | 10 μM | 1 h | DMSO | Induces PARP cleavage by inhibiting proseasome activity | 24321833 |
| MDA-MB-231 | Growth Inhibition Assay | 1 μM | 72 h | DMSO | IC50=0.18 μM | 24153206 |
| 293T | Cytotoxic Assay | 10 μM | 72 h | DMSO | IC50<2 μM | 24625088 |
| 293T | Function Assay | 10 μM | 24 h | DMSO | Moderately induces heat-shock | 24625088 |
| NCI-H929 | Cytotoxic Assay | 1 μM | 72 h | DMSO | IC50=0.17 μM | 24625088 |
| A-549 | Cytotoxic Assay | 40 μM | 48 h | DMSO | IC50<10 μM | 24697496 |
| MCF-7 | Cytotoxic Assay | 40 μM | 48 h | DMSO | IC50=7.3 μM | 24697496 |
| SW-480 | Cytotoxic Assay | 40 μM | 48 h | DMSO | IC50=4 μM | 24697496 |
| HL-60 | Cytotoxic Assay | 40 μM | 48 h | DMSO | IC50<10 μM | 24697496 |
| SMMC-7721 | Cytotoxic Assay | 40 μM | 48 h | DMSO | IC50=7.1 μM | 24697496 |
| LPS-stimulated RAW264.7 cells | Function Assay | 25 μM | DMSO | Inhibits nitric oxide production with IC50 of 0.1 μM | 24697496 | |
| lymphoblastoid | Function assay | IC50 = 0.002 μM | 17996987 | |||
| LCL | Function assay | 12 h | IC50 = 0.002 μM | 20687609 | ||
| HL-60 | Function assay | IC50 = 0.068 μM | 15780623 | |||
| IPC227F | Function assay | 1 h | IC50 = 0.077 μM | 16220988 | ||
| RAW264.7 | Antiinflammatory activity assay | 18 h | IC50 = 0.08 μM | 22620677 | ||
| RAW264.7 | Antiinflammatory activity assay | 18 h | IC50 = 0.1 μM | 23819871 | ||
| RAW264.7 | Function assay | IC50 = 0.1 μM | 24597894 | |||
| RAW264.7 | Function assay | 18 h | IC50 = 0.1 μM | 24219809 | ||
| RAW264.7 | Function assay | 18 h | IC50 = 0.15 μM | 23327668 | ||
| RAW264.7 | Function assay | 18 h | IC50 = 0.15 μM | 26757019 | ||
| RAW264.7 | Antiinflammatory activity assay | 18 h | IC50 = 0.18 μM | 27203291 | ||
| RAW264.7 | Antiinflammatory activity assay | 1 h | IC50 = 0.2 μM | 29338260 | ||
| MDA-MB-231 | Cytotoxicity assay | IC50 = 0.25 μM | 18598018 | |||
| MCF7 | Cytotoxicity assay | IC50 = 0.3 μM | 18598018 | |||
| RAW264.7 | Function assay | 18 h | IC50 = 0.35 μM | 21044847 | ||
| RAW264.7 | Antiinflammatory activity assay | IC50 = 0.439 μM | 21561060 | |||
| HEK293 | Function assay | 2 h | IC50 = 0.6 μM | 23540790 | ||
| RAW264.7 | Toxicity assay | IC50 = 0.63 μM | 22858297 | |||
| lymphoblastoid | Function assay | IC50 = 1.077 μM | 17996987 | |||
| LCL | Function assay | 12 h | IC50 = 1.077 μM | 20687609 | ||
| HL-60 | Function assay | IC50 = 1.4 μM | 15780623 | |||
| HL-60 | Function assay | IC50 = 4.5 μM | 15780623 | |||
| C8166 | Growth Inhibition Assay | IC50=345.338 μM | SANGER | |||
| P30-OHK | Growth Inhibition Assay | IC50=283.847 μM | SANGER | |||
| NCI-H1838 | Growth Inhibition Assay | IC50=271.456 μM | SANGER | |||
| THP-1 | Growth Inhibition Assay | IC50=264.738 μM | SANGER | |||
| MS-1 | Growth Inhibition Assay | IC50=239.121 μM | SANGER | |||
| REH | Growth Inhibition Assay | IC50=236.626 μM | SANGER | |||
| TE-441-T | Growth Inhibition Assay | IC50=199.739 μM | SANGER | |||
| TALL-1 | Growth Inhibition Assay | IC50=198.304 μM | SANGER | |||
| SF539 | Growth Inhibition Assay | IC50=192.728 μM | SANGER | |||
| NCI-H187 | Growth Inhibition Assay | IC50=190.064 μM | SANGER | |||
| NCI-H226 | Growth Inhibition Assay | IC50=188.866 μM | SANGER | |||
| IMR-5 | Growth Inhibition Assay | IC50=181.571 μM | SANGER | |||
| NCI-H1417 | Growth Inhibition Assay | IC50=180.331 μM | SANGER | |||
| TUR | Growth Inhibition Assay | IC50=167.87 μM | SANGER | |||
| NCI-H1770 | Growth Inhibition Assay | IC50=156.279 μM | SANGER | |||
| MDA-MB-134-VI | Growth Inhibition Assay | IC50=148.268 μM | SANGER | |||
| NB14 | Growth Inhibition Assay | IC50=147.082 μM | SANGER | |||
| EW-12 | Growth Inhibition Assay | IC50=144.699 μM | SANGER | |||
| SUP-T1 | Growth Inhibition Assay | IC50=143.708 μM | SANGER | |||
| KP-N-YS | Growth Inhibition Assay | IC50=139.736 μM | SANGER | |||
| BE-13 | Growth Inhibition Assay | IC50=134.044 μM | SANGER | |||
| NCI-H510A | Growth Inhibition Assay | IC50=127.32 μM | SANGER | |||
| DMS-153 | Growth Inhibition Assay | IC50=121.745 μM | SANGER | |||
| SK-MEL-1 | Growth Inhibition Assay | IC50=118.009 μM | SANGER | |||
| DMS-79 | Growth Inhibition Assay | IC50=117.382 μM | SANGER | |||
| DG-75 | Growth Inhibition Assay | IC50=113.352 μM | SANGER | |||
| MN-60 | Growth Inhibition Assay | IC50=109.69 μM | SANGER | |||
| WSU-NHL | Growth Inhibition Assay | IC50=109.671 μM | SANGER | |||
| BV-173 | Growth Inhibition Assay | IC50=108.728 μM | SANGER | |||
| EW-22 | Growth Inhibition Assay | IC50=106.19 μM | SANGER | |||
| NCI-H889 | Growth Inhibition Assay | IC50=104.242 μM | SANGER | |||
| NCI-H446 | Growth Inhibition Assay | IC50=99.7588 μM | SANGER | |||
| NCI-H720 | Growth Inhibition Assay | IC50=98.4061 μM | SANGER | |||
| NB7 | Growth Inhibition Assay | IC50=95.7786 μM | SANGER | |||
| EW-3 | Growth Inhibition Assay | IC50=94.9081 μM | SANGER | |||
| ECC4 | Growth Inhibition Assay | IC50=93.8269 μM | SANGER | |||
| KY821 | Growth Inhibition Assay | IC50=91.6551 μM | SANGER | |||
| RPMI-8226 | Growth Inhibition Assay | IC50=84.2107 μM | SANGER | |||
| LU-134-A | Growth Inhibition Assay | IC50=83.1351 μM | SANGER | |||
| NCI-H716 | Growth Inhibition Assay | IC50=82.9075 μM | SANGER | |||
| RS4-11 | Growth Inhibition Assay | IC50=82.2505 μM | SANGER | |||
| COLO-668 | Growth Inhibition Assay | IC50=81.5884 μM | SANGER | |||
| NCI-H2171 | Growth Inhibition Assay | IC50=79.4136 μM | SANGER | |||
| NCI-H526 | Growth Inhibition Assay | IC50=78.5877 μM | SANGER | |||
| NCI-H322M | Growth Inhibition Assay | IC50=78.3709 μM | SANGER | |||
| HCC1187 | Growth Inhibition Assay | IC50=77.6122 μM | SANGER | |||
| SK-NEP-1 | Growth Inhibition Assay | IC50=75.0754 μM | SANGER | |||
| DOHH-2 | Growth Inhibition Assay | IC50=74.9514 μM | SANGER | |||
| NCI-H1155 | Growth Inhibition Assay | IC50=74.9367 μM | SANGER | |||
| HCC1599 | Growth Inhibition Assay | IC50=74.8732 μM | SANGER | |||
| RPMI-8866 | Growth Inhibition Assay | IC50=74.7509 μM | SANGER | |||
| ATN-1 | Growth Inhibition Assay | IC50=74.505 μM | SANGER | |||
| NCI-H1436 | Growth Inhibition Assay | IC50=72.7456 μM | SANGER | |||
| SCC-15 | Growth Inhibition Assay | IC50=72.34 μM | SANGER | |||
| NCI-H82 | Growth Inhibition Assay | IC50=71.9507 μM | SANGER | |||
| NCI-H1694 | Growth Inhibition Assay | IC50=71.032 μM | SANGER | |||
| KARPAS-299 | Growth Inhibition Assay | IC50=70.4447 μM | SANGER | |||
| NB5 | Growth Inhibition Assay | IC50=70.3468 μM | SANGER | |||
| MHH-CALL-2 | Growth Inhibition Assay | IC50=70.06 μM | SANGER | |||
| UACC-812 | Growth Inhibition Assay | IC50=69.5209 μM | SANGER | |||
| NCI-H1522 | Growth Inhibition Assay | IC50=69.0047 μM | SANGER | |||
| U-698-M | Growth Inhibition Assay | IC50=68.5687 μM | SANGER | |||
| SK-MEL-2 | Growth Inhibition Assay | IC50=63.9892 μM | SANGER | |||
| TGBC24TKB | Growth Inhibition Assay | IC50=62.1491 μM | SANGER | |||
| LOXIMVI | Growth Inhibition Assay | IC50=61.8266 μM | SANGER | |||
| NCI-H2196 | Growth Inhibition Assay | IC50=61.231 μM | SANGER | |||
| SCH | Growth Inhibition Assay | IC50=60.9638 μM | SANGER | |||
| RPMI-8402 | Growth Inhibition Assay | IC50=58.9526 μM | SANGER | |||
| NCI-H1395 | Growth Inhibition Assay | IC50=58.8172 μM | SANGER | |||
| KP-N-RT-BM-1 | Growth Inhibition Assay | IC50=56.6638 μM | SANGER | |||
| SW962 | Growth Inhibition Assay | IC50=54.8357 μM | SANGER | |||
| TC-YIK | Growth Inhibition Assay | IC50=50.0363 μM | SANGER | |||
| A3-KAW | Growth Inhibition Assay | IC50=49.8061 μM | SANGER | |||
| HT | Growth Inhibition Assay | IC50=45.7007 μM | SANGER | |||
| SW954 | Growth Inhibition Assay | IC50=47.4128 μM | SANGER | |||
| CW-2 | Growth Inhibition Assay | IC50=44.8342 μM | SANGER | |||
| EoL-1- | Growth Inhibition Assay | IC50=44.1568 μM | SANGER | |||
| MPP-89 | Growth Inhibition Assay | IC50=42.5875 μM | SANGER | |||
| MV-4-11 | Growth Inhibition Assay | IC50=42.9067 μM | SANGER | |||
| SBC-1 | Growth Inhibition Assay | IC50=42.1806 μM | SANGER | |||
| MLMA | Growth Inhibition Assay | IC50=41.7595 μM | SANGER | |||
| DEL | Growth Inhibition Assay | IC50=41.4405 μM | SANGER | |||
| LB996-RCC | Growth Inhibition Assay | IC50=40.8716 μM | SANGER | |||
| NCI-H64 | Growth Inhibition Assay | IC50=40.0948 μM | SANGER | |||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=39.7388 μM | SANGER | |||
| NCI-SNU-16 | Growth Inhibition Assay | IC50=38.5653 μM | SANGER | |||
| LC-2-ad | Growth Inhibition Assay | IC50=39.4337 μM | SANGER | |||
| RCC10RGB | Growth Inhibition Assay | IC50=38.2083 μM | SANGER | |||
| NCI-H1299 | Growth Inhibition Assay | IC50=38.1603 μM | SANGER | |||
| K-562 | Growth Inhibition Assay | IC50=37.0864 μM | SANGER | |||
| CGTH-W-1 | Growth Inhibition Assay | IC50=36.9048 μM | SANGER | |||
| KP-N-YN | Growth Inhibition Assay | IC50=34.9057 μM | SANGER | |||
| TE-11 | Growth Inhibition Assay | IC50=34.4822 μM | SANGER | |||
| L-428 | Growth Inhibition Assay | IC50=34.7536 μM | SANGER | |||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=34.2993 μM | SANGER | |||
| EW-13 | Growth Inhibition Assay | IC50=33.8969 μM | SANGER | |||
| NB69 | Growth Inhibition Assay | IC50=33.6454 μM | SANGER | |||
| EW-24 | Growth Inhibition Assay | IC50=32.3474 μM | SANGER | |||
| L-363 | Growth Inhibition Assay | IC50=32.2144 μM | SANGER | |||
| SNU-C1 | Growth Inhibition Assay | IC50=31.3126 μM | SANGER | |||
| JAR | Growth Inhibition Assay | IC50=31.3799 μM | SANGER | |||
| NCI-H2107 | Growth Inhibition Assay | IC50=31.2338 μM | SANGER | |||
| NB6 | Growth Inhibition Assay | IC50=30.9503 μM | SANGER | |||
| SIG-M5 | Growth Inhibition Assay | IC50=30.7952 μM | SANGER | |||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=29.9281 μM | SANGER | |||
| COLO-800 | Growth Inhibition Assay | IC50=28.2956 μM | SANGER | |||
| ETK-1 | Growth Inhibition Assay | IC50=28.3446 μM | SANGER | |||
| LU-165 | Growth Inhibition Assay | IC50=28.0861 μM | SANGER | |||
| COR-L279 | Growth Inhibition Assay | IC50=26.7922 μM | SANGER | |||
| U-87-MG | Growth Inhibition Assay | IC50=26.7644 μM | SANGER | |||
| NCI-H1963 | Growth Inhibition Assay | IC50=26.0623 μM | SANGER | |||
| ST486 | Growth Inhibition Assay | IC50=25.1113 μM | SANGER | |||
| LS-123 | Growth Inhibition Assay | IC50=24.9012 μM | SANGER | |||
| NB1 | Growth Inhibition Assay | IC50=24.6939 μM | SANGER | |||
| CPC-N | Growth Inhibition Assay | IC50=24.0201 μM | SANGER | |||
| EHEB | Growth Inhibition Assay | IC50=21.6731 μM | SANGER | |||
| CHP-126 | Growth Inhibition Assay | IC50=21.6181 μM | SANGER | |||
| GR-ST | Growth Inhibition Assay | IC50=21.417 μM | SANGER | |||
| NCI-H345 | Growth Inhibition Assay | IC50=21.0643 μM | SANGER | |||
| RPMI-6666 | Growth Inhibition Assay | IC50=21.3602 μM | SANGER | |||
| HDLM-2 | Growth Inhibition Assay | IC50=20.8821 μM | SANGER | |||
| NCI-H1304 | Growth Inhibition Assay | IC50=21.0311 μM | SANGER | |||
| IM-9 | Growth Inhibition Assay | IC50=20.6224 μM | SANGER | |||
| P31-FUJ | Growth Inhibition Assay | IC50=20.4753 μM | SANGER | |||
| HL-60 | Growth Inhibition Assay | IC50=20.1965 μM | SANGER | |||
| KMOE-2 | Growth Inhibition Assay | IC50=19.6482 μM | SANGER | |||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=19.4066 μM | SANGER | |||
| MOLT-4 | Growth Inhibition Assay | IC50=18.8208 μM | SANGER | |||
| Daudi | Growth Inhibition Assay | IC50=18.9231 μM | SANGER | |||
| CAL-148 | Growth Inhibition Assay | IC50=17.9796 μM | SANGER | |||
| HCC2157 | Growth Inhibition Assay | IC50=17.4755 μM | SANGER | |||
| LS-1034 | Growth Inhibition Assay | IC50=17.6818 μM | SANGER | |||
| BOKU | Growth Inhibition Assay | IC50=15.9608 μM | SANGER | |||
| GOTO | Growth Inhibition Assay | IC50=16.9617 μM | SANGER | |||
| COLO-824 | Growth Inhibition Assay | IC50=14.7994 μM | SANGER | |||
| BC-3 | Growth Inhibition Assay | IC50=15.398 μM | SANGER | |||
| MSTO-211H | Growth Inhibition Assay | IC50=14.7448 μM | SANGER | |||
| JVM-2 | Growth Inhibition Assay | IC50=14.7735 μM | SANGER | |||
| DB | Growth Inhibition Assay | IC50=13.9885 μM | SANGER | |||
| 697 | Growth Inhibition Assay | IC50=14.4511 μM | SANGER | |||
| TE-12 | Growth Inhibition Assay | IC50=13.6994 μM | SANGER | |||
| NCI-N87 | Growth Inhibition Assay | IC50=13.736 μM | SANGER | |||
| EB2 | Growth Inhibition Assay | IC50=13.8505 μM | SANGER | |||
| MHH-NB-11 | Growth Inhibition Assay | IC50=13.2902 μM | SANGER | |||
| KU812 | Growth Inhibition Assay | IC50=13.6124 μM | SANGER | |||
| NB13 | Growth Inhibition Assay | IC50=12.9783 μM | SANGER | |||
| MRK-nu-1 | Growth Inhibition Assay | IC50=13.195 μM | SANGER | |||
| COR-L88 | Growth Inhibition Assay | IC50=12.9382 μM | SANGER | |||
| K5 | Growth Inhibition Assay | IC50=12.9462 μM | SANGER | |||
| KARPAS-422 | Growth Inhibition Assay | IC50=12.7496 μM | SANGER | |||
| LU-139 | Growth Inhibition Assay | IC50=12.9026 μM | SANGER | |||
| NOS-1 | Growth Inhibition Assay | IC50=12.0345 μM | SANGER | |||
| AM-38 | Growth Inhibition Assay | IC50=12.5633 μM | SANGER | |||
| A498 | Growth Inhibition Assay | IC50=12.7069 μM | SANGER | |||
| SK-MM-2 | Growth Inhibition Assay | IC50=11.8061 μM | SANGER | |||
| NCI-H524 | Growth Inhibition Assay | IC50=11.9822 μM | SANGER | |||
| EW-11 | Growth Inhibition Assay | IC50=11.5186 μM | SANGER | |||
| TGBC1TKB | Growth Inhibition Assay | IC50=11.4102 μM | SANGER | |||
| NCI-H1648 | Growth Inhibition Assay | IC50=11.0965 μM | SANGER | |||
| SR | Growth Inhibition Assay | IC50=11.0185 μM | SANGER | |||
| EC-GI-10 | Growth Inhibition Assay | IC50=10.7031 μM | SANGER | |||
| SCLC-21H | Growth Inhibition Assay | IC50=10.6596 μM | SANGER | |||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=10.4969 μM | SANGER | |||
| CA46 | Growth Inhibition Assay | IC50=10.361 μM | SANGER | |||
| NH-12 | Growth Inhibition Assay | IC50=10.2433 μM | SANGER | |||
| CTV-1 | Growth Inhibition Assay | IC50=10.0979 μM | SANGER | |||
| IST-MEL1 | Growth Inhibition Assay | IC50=9.74198 μM | SANGER | |||
| JiyoyeP-2003 | Growth Inhibition Assay | IC50=9.29317 μM | SANGER | |||
| SJSA-1 | Growth Inhibition Assay | IC50=9.09091 μM | SANGER | |||
| MC116 | Growth Inhibition Assay | IC50=8.9794 μM | SANGER | |||
| D-283MED | Growth Inhibition Assay | IC50=8.91719 μM | SANGER | |||
| OMC-1 | Growth Inhibition Assay | IC50=8.52191 μM | SANGER | |||
| RL95-2 | Growth Inhibition Assay | IC50=8.10842 μM | SANGER | |||
| NB10 | Growth Inhibition Assay | IC50=7.99556 μM | SANGER | |||
| MZ1-PC | Growth Inhibition Assay | IC50=7.86558 μM | SANGER | |||
| LB1047-RCC | Growth Inhibition Assay | IC50=7.72231 μM | SANGER | |||
| SK-N-DZ | Growth Inhibition Assay | IC50=7.71089 μM | SANGER | |||
| NOMO-1 | Growth Inhibition Assay | IC50=7.24254 μM | SANGER | |||
| SHP-77 | Growth Inhibition Assay | IC50=7.2243 μM | SANGER | |||
| OCI-AML2 | Growth Inhibition Assay | IC50=7.00326 μM | SANGER | |||
| NALM-6 | Growth Inhibition Assay | IC50=6.86754 μM | SANGER | |||
| KASUMI-1 | Growth Inhibition Assay | IC50=6.84787 μM | SANGER | |||
| EM-2 | Growth Inhibition Assay | IC50=6.67099 μM | SANGER | |||
| NMC-G1 | Growth Inhibition Assay | IC50=6.71895 μM | SANGER | |||
| SK-N-FI | Growth Inhibition Assay | IC50=6.45854 μM | SANGER | |||
| U-266 | Growth Inhibition Assay | IC50=6.51926 μM | SANGER | |||
| HUTU-80 | Growth Inhibition Assay | IC50=6.36897 μM | SANGER | |||
| TGW | Growth Inhibition Assay | IC50=6.45593 μM | SANGER | |||
| A4-Fuk | Growth Inhibition Assay | IC50=6.08118 μM | SANGER | |||
| NCI-H1581 | Growth Inhibition Assay | IC50=6.23849 μM | SANGER | |||
| ARH-77 | Growth Inhibition Assay | IC50=5.67087 μM | SANGER | |||
| ALL-PO | Growth Inhibition Assay | IC50=5.63795 μM | SANGER | |||
| GCIY | Growth Inhibition Assay | IC50=5.47236 μM | SANGER | |||
| Calu-6 | Growth Inhibition Assay | IC50=5.622 μM | SANGER | |||
| SIMA | Growth Inhibition Assay | IC50=5.30765 μM | SANGER | |||
| RL | Growth Inhibition Assay | IC50=5.37541 μM | SANGER | |||
| RKO | Growth Inhibition Assay | IC50=5.23422 μM | SANGER | |||
| NCI-H209 | Growth Inhibition Assay | IC50=5.19352 μM | SANGER | |||
| BT-474 | Growth Inhibition Assay | IC50=5.23102 μM | SANGER | |||
| EB-3 | Growth Inhibition Assay | IC50=5.03041 μM | SANGER | |||
| GT3TKB | Growth Inhibition Assay | IC50=5.17662 μM | SANGER | |||
| HAL-01 | Growth Inhibition Assay | IC50=4.57034 μM | SANGER | |||
| LP-1 | Growth Inhibition Assay | IC50=4.72371 μM | SANGER | |||
| BC-1 | Growth Inhibition Assay | IC50=5.00447 μM | SANGER | |||
| LB647-SCLC | Growth Inhibition Assay | IC50=4.56308 μM | SANGER | |||
| ES5 | Growth Inhibition Assay | IC50=4.40255 μM | SANGER | |||
| ES3 | Growth Inhibition Assay | IC50=4.32824 μM | SANGER | |||
| YT | Growth Inhibition Assay | IC50=4.35424 μM | SANGER | |||
| NCI-H1650 | Growth Inhibition Assay | IC50=4.15797 μM | SANGER | |||
| D-336MG | Growth Inhibition Assay | IC50=4.01166 μM | SANGER | |||
| TE-6 | Growth Inhibition Assay | IC50=3.94561 μM | SANGER | |||
| NKM-1 | Growth Inhibition Assay | IC50=3.77378 μM | SANGER | |||
| COLO-320-HSR | Growth Inhibition Assay | IC50=3.75634 μM | SANGER | |||
| SKM-1 | Growth Inhibition Assay | IC50=3.71376 μM | SANGER | |||
| KMS-12-PE | Growth Inhibition Assay | IC50=3.67723 μM | SANGER | |||
| SNB75 | Growth Inhibition Assay | IC50=3.60103 μM | SANGER | |||
| NB12 | Growth Inhibition Assay | IC50=3.59888 μM | SANGER | |||
| MEG-01 | Growth Inhibition Assay | IC50=3.5968 μM | SANGER | |||
| HCC2218 | Growth Inhibition Assay | IC50=3.46937 μM | SANGER | |||
| NCI-H748 | Growth Inhibition Assay | IC50=3.44266 μM | SANGER | |||
| RH-1 | Growth Inhibition Assay | IC50=3.38748 μM | SANGER | |||
| SCC-3 | Growth Inhibition Assay | IC50=3.10848 μM | SANGER | |||
| ES4 | Growth Inhibition Assay | IC50=3.06111 μM | SANGER | |||
| KG-1 | Growth Inhibition Assay | IC50=2.88791 μM | SANGER | |||
| SW982 | Growth Inhibition Assay | IC50=2.5148 μM | SANGER | |||
| MFM-223 | Growth Inhibition Assay | IC50=2.50871 μM | SANGER | |||
| HCE-T | Growth Inhibition Assay | IC50=2.44883 μM | SANGER | |||
| ECC12 | Growth Inhibition Assay | IC50=2.3794 μM | SANGER | |||
| KM-H2 | Growth Inhibition Assay | IC50=2.29043 μM | SANGER | |||
| MC-CAR | Growth Inhibition Assay | IC50=2.2295 μM | SANGER | |||
| QIMR-WIL | Growth Inhibition Assay | IC50=2.16762 μM | SANGER | |||
| no-11 | Growth Inhibition Assay | IC50=2.03104 μM | SANGER | |||
| DJM-1 | Growth Inhibition Assay | IC50=2.02552 μM | SANGER | |||
| EW-18 | Growth Inhibition Assay | IC50=2.02337 μM | SANGER | |||
| IST-SL2 | Growth Inhibition Assay | IC50=2.01252 μM | SANGER | |||
| JVM-3 | Growth Inhibition Assay | IC50=1.93904 μM | SANGER | |||
| TE-15 | Growth Inhibition Assay | IC50=1.92373 μM | SANGER | |||
| BB30-HNC | Growth Inhibition Assay | IC50=1.72685 μM | SANGER | |||
| SU-DHL-1 | Growth Inhibition Assay | IC50=1.71281 μM | SANGER | |||
| LS-411N | Growth Inhibition Assay | IC50=1.69807 μM | SANGER | |||
| NCI-H2141 | Growth Inhibition Assay | IC50=1.67317 μM | SANGER | |||
| D-502MG | Growth Inhibition Assay | IC50=1.67211 μM | SANGER | |||
| NCI-H2227 | Growth Inhibition Assay | IC50=1.61561 μM | SANGER | |||
| LC-1F | Growth Inhibition Assay | IC50=1.55198 μM | SANGER | |||
| NCI-H2081 | Growth Inhibition Assay | IC50=1.55196 μM | SANGER | |||
| GI-1 | Growth Inhibition Assay | IC50=1.47131 μM | SANGER | |||
| DMS-114 | Growth Inhibition Assay | IC50=1.44539 μM | SANGER | |||
| Raji | Growth Inhibition Assay | IC50=1.4185 μM | SANGER | |||
| IST-MES1 | Growth Inhibition Assay | IC50=1.40208 μM | SANGER | |||
| HC-1 | Growth Inhibition Assay | IC50=1.3817 μM | SANGER | |||
| NCI-H128 | Growth Inhibition Assay | IC50=1.35814 μM | SANGER | |||
| EW-16 | Growth Inhibition Assay | IC50=1.31347 μM | SANGER | |||
| HCE-4 | Growth Inhibition Assay | IC50=1.30221 μM | SANGER | |||
| SW684 | Growth Inhibition Assay | IC50=1.28659 μM | SANGER | |||
| NCI-H719 | Growth Inhibition Assay | IC50=1.27411 μM | SANGER | |||
| PSN1 | Growth Inhibition Assay | IC50=1.27016 μM | SANGER | |||
| IA-LM | Growth Inhibition Assay | IC50=1.24116 μM | SANGER | |||
| NCI-H23 | Growth Inhibition Assay | IC50=1.2041 μM | SANGER | |||
| MFH-ino | Growth Inhibition Assay | IC50=1.17501 μM | SANGER | |||
| LU-65 | Growth Inhibition Assay | IC50=1.12753 μM | SANGER | |||
| KURAMOCHI | Growth Inhibition Assay | IC50=1.12374 μM | SANGER | |||
| L-540 | Growth Inhibition Assay | IC50=1.11839 μM | SANGER | |||
| ES1 | Growth Inhibition Assay | IC50=1.07921 μM | SANGER | |||
| KGN | Growth Inhibition Assay | IC50=1.05045 μM | SANGER | |||
| KARPAS-45 | Growth Inhibition Assay | IC50=1.04016 μM | SANGER | |||
| EKVX | Growth Inhibition Assay | IC50=1.03442 μM | SANGER | |||
| SF126 | Growth Inhibition Assay | IC50=0.98971 μM | SANGER | |||
| TE-10 | Growth Inhibition Assay | IC50=0.9643 μM | SANGER | |||
| HCC2998 | Growth Inhibition Assay | IC50=0.93854 μM | SANGER | |||
| COLO-684 | Growth Inhibition Assay | IC50=0.90658 μM | SANGER | |||
| ES7 | Growth Inhibition Assay | IC50=0.8965 μM | SANGER | |||
| KM12 | Growth Inhibition Assay | IC50=0.85466 μM | SANGER | |||
| Becker | Growth Inhibition Assay | IC50=0.79621 μM | SANGER | |||
| CTB-1 | Growth Inhibition Assay | IC50=0.77955 μM | SANGER | |||
| GB-1 | Growth Inhibition Assay | IC50=0.72124 μM | SANGER | |||
| SNU-C2B | Growth Inhibition Assay | IC50=0.70739 μM | SANGER | |||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=0.69545 μM | SANGER | |||
| BL-70 | Growth Inhibition Assay | IC50=0.69388 μM | SANGER | |||
| NCI-H1355 | Growth Inhibition Assay | IC50=0.68619 μM | SANGER | |||
| LS-513 | Growth Inhibition Assay | IC50=0.66751 μM | SANGER | |||
| SW872 | Growth Inhibition Assay | IC50=0.65729 μM | SANGER | |||
| SF268 | Growth Inhibition Assay | IC50=0.65641 μM | SANGER | |||
| NCI-H2126 | Growth Inhibition Assay | IC50=0.62669 μM | SANGER | |||
| TE-9 | Growth Inhibition Assay | IC50=0.61033 μM | SANGER | |||
| NCI-H1882 | Growth Inhibition Assay | IC50=0.59036 μM | SANGER | |||
| BB65-RCC | Growth Inhibition Assay | IC50=0.56811 μM | SANGER | |||
| MONO-MAC-6 | Growth Inhibition Assay | IC50=0.53611 μM | SANGER | |||
| Mo-T | Growth Inhibition Assay | IC50=0.51762 μM | SANGER | |||
| EVSA-T | Growth Inhibition Assay | IC50=0.49911 μM | SANGER | |||
| BB49-HNC | Growth Inhibition Assay | IC50=0.49096 μM | SANGER | |||
| A704 | Growth Inhibition Assay | IC50=0.48692 μM | SANGER | |||
| OS-RC-2 | Growth Inhibition Assay | IC50=0.47972 μM | SANGER | |||
| CCRF-CEM | Growth Inhibition Assay | IC50=0.47674 μM | SANGER | |||
| KALS-1 | Growth Inhibition Assay | IC50=0.46584 μM | SANGER | |||
| TE-1 | Growth Inhibition Assay | IC50=0.45119 μM | SANGER | |||
| LC4-1 | Growth Inhibition Assay | IC50=0.43607 μM | SANGER | |||
| NB17 | Growth Inhibition Assay | IC50=0.4297 μM | SANGER | |||
| 8-MG-BA | Growth Inhibition Assay | IC50=0.39837 μM | SANGER | |||
| NCI-H1092 | Growth Inhibition Assay | IC50=0.38844 μM | SANGER | |||
| NCI-H747 | Growth Inhibition Assay | IC50=0.37103 μM | SANGER | |||
| GDM-1 | Growth Inhibition Assay | IC50=0.35104 μM | SANGER | |||
| TE-8 | Growth Inhibition Assay | IC50=0.34279 μM | SANGER | |||
| HH | Growth Inhibition Assay | IC50=0.32897 μM | SANGER | |||
| NCCIT | Growth Inhibition Assay | IC50=0.31783 μM | SANGER | |||
| KLE | Growth Inhibition Assay | IC50=0.31306 μM | SANGER | |||
| LAN-6 | Growth Inhibition Assay | IC50=0.313 μM | SANGER | |||
| CMK | Growth Inhibition Assay | IC50=0.3112 μM | SANGER | |||
| KNS-81-FD | Growth Inhibition Assay | IC50=0.30323 μM | SANGER | |||
| MOLT-16 | Growth Inhibition Assay | IC50=0.29524 μM | SANGER | |||
| K052 | Growth Inhibition Assay | IC50=0.2899 μM | SANGER | |||
| C2BBe1 | Growth Inhibition Assay | IC50=0.27907 μM | SANGER | |||
| CP67-MEL | Growth Inhibition Assay | IC50=0.2673 μM | SANGER | |||
| MZ7-mel | Growth Inhibition Assay | IC50=0.26374 μM | SANGER | |||
| LOUCY | Growth Inhibition Assay | IC50=0.25456 μM | SANGER | |||
| TK10 | Growth Inhibition Assay | IC50=0.25435 μM | SANGER | |||
| RXF393 | Growth Inhibition Assay | IC50=0.25015 μM | SANGER | |||
| ES8 | Growth Inhibition Assay | IC50=0.24763 μM | SANGER | |||
| COLO-829 | Growth Inhibition Assay | IC50=0.24257 μM | SANGER | |||
| LB373-MEL-D | Growth Inhibition Assay | IC50=0.24198 μM | SANGER | |||
| HD-MY-Z | Growth Inhibition Assay | IC50=0.23303 μM | SANGER | |||
| SK-PN-DW | Growth Inhibition Assay | IC50=0.2319 μM | SANGER | |||
| ACN | Growth Inhibition Assay | IC50=0.22638 μM | SANGER | |||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.22257 μM | SANGER | |||
| SK-UT-1 | Growth Inhibition Assay | IC50=0.22049 μM | SANGER | |||
| LAMA-84 | Growth Inhibition Assay | IC50=0.21851 μM | SANGER | |||
| EW-1 | Growth Inhibition Assay | IC50=0.21047 μM | SANGER | |||
| GAK | Growth Inhibition Assay | IC50=0.20534 μM | SANGER | |||
| IST-SL1 | Growth Inhibition Assay | IC50=0.20094 μM | SANGER | |||
| DU-4475 | Growth Inhibition Assay | IC50=0.19658 μM | SANGER | |||
| LB831-BLC | Growth Inhibition Assay | IC50=0.1934 μM | SANGER | |||
| GI-ME-N | Growth Inhibition Assay | IC50=0.19306 μM | SANGER | |||
| SK-LMS-1 | Growth Inhibition Assay | IC50=0.19303 μM | SANGER | |||
| D-392MG | Growth Inhibition Assay | IC50=0.19115 μM | SANGER | |||
| HEL | Growth Inhibition Assay | IC50=0.18517 μM | SANGER | |||
| MZ2-MEL | Growth Inhibition Assay | IC50=0.17559 μM | SANGER | |||
| CESS | Growth Inhibition Assay | IC50=0.1706 μM | SANGER | |||
| PF-382 | Growth Inhibition Assay | IC50=0.16706 μM | SANGER | |||
| A253 | Growth Inhibition Assay | IC50=0.16128 μM | SANGER | |||
| D-263MG | Growth Inhibition Assay | IC50=0.16006 μM | SANGER | |||
| CAS-1 | Growth Inhibition Assay | IC50=0.15482 μM | SANGER | |||
| NCI-H69 | Growth Inhibition Assay | IC50=0.15141 μM | SANGER | |||
| KINGS-1 | Growth Inhibition Assay | IC50=0.1479 μM | SANGER | |||
| TE-5 | Growth Inhibition Assay | IC50=0.14278 μM | SANGER | |||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.14247 μM | SANGER | |||
| HT-144 | Growth Inhibition Assay | IC50=0.13895 μM | SANGER | |||
| KE-37 | Growth Inhibition Assay | IC50=0.13278 μM | SANGER | |||
| ONS-76 | Growth Inhibition Assay | IC50=0.12935 μM | SANGER | |||
| NEC8 | Growth Inhibition Assay | IC50=0.11995 μM | SANGER | |||
| UACC-257 | Growth Inhibition Assay | IC50=0.11927 μM | SANGER | |||
| ML-2 | Growth Inhibition Assay | IC50=0.11806 μM | SANGER | |||
| HOP-62 | Growth Inhibition Assay | IC50=0.10949 μM | SANGER | |||
| OVCAR-4 | Growth Inhibition Assay | IC50=0.10938 μM | SANGER | |||
| OPM-2 | Growth Inhibition Assay | IC50=0.10474 μM | SANGER | |||
| A388 | Growth Inhibition Assay | IC50=0.09065 μM | SANGER | |||
| no-10 | Growth Inhibition Assay | IC50=0.08909 μM | SANGER | |||
| LB771-HNC | Growth Inhibition Assay | IC50=0.08036 μM | SANGER | |||
| CP66-MEL | Growth Inhibition Assay | IC50=0.075 μM | SANGER | |||
| MMAC-SF | Growth Inhibition Assay | IC50=0.07268 μM | SANGER | |||
| D-247MG | Growth Inhibition Assay | IC50=0.07209 μM | SANGER | |||
| LXF-289 | Growth Inhibition Assay | IC50=0.07066 μM | SANGER | |||
| BL-41 | Growth Inhibition Assay | IC50=0.06947 μM | SANGER | |||
| KS-1 | Growth Inhibition Assay | IC50=0.06458 μM | SANGER | |||
| D-542MG | Growth Inhibition Assay | IC50=0.05957 μM | SANGER | |||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=0.05772 μM | SANGER | |||
| DSH1 | Growth Inhibition Assay | IC50=0.05289 μM | SANGER | |||
| KNS-42 | Growth Inhibition Assay | IC50=0.04441 μM | SANGER | |||
| SH-4 | Growth Inhibition Assay | IC50=0.0431 μM | SANGER | |||
| LB2518-MEL | Growth Inhibition Assay | IC50=0.0376 μM | SANGER | |||
| OCUB-M | Growth Inhibition Assay | IC50=0.03737 μM | SANGER | |||
| A101D | Growth Inhibition Assay | IC50=0.03279 μM | SANGER | |||
| ES6 | Growth Inhibition Assay | IC50=0.01306 μM | SANGER | |||
| MFH-ino | Growth Inhibition Assay | IC50=0.1111 μM | SANGER | |||
| TE-8 | Growth Inhibition Assay | IC50=0.27009 μM | SANGER | |||
| A101D | Growth Inhibition Assay | IC50=0.30094 μM | SANGER | |||
| ES6 | Growth Inhibition Assay | IC50=0.33014 μM | SANGER | |||
| HT-144 | Growth Inhibition Assay | IC50=0.33422 μM | SANGER | |||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.4231 μM | SANGER | |||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=0.42592 μM | SANGER | |||
| ML-2 | Growth Inhibition Assay | IC50=0.47349 μM | SANGER | |||
| LB831-BLC | Growth Inhibition Assay | IC50=0.47626 μM | SANGER | |||
| BE-13 | Growth Inhibition Assay | IC50=0.56207 μM | SANGER | |||
| HH | Growth Inhibition Assay | IC50=0.57053 μM | SANGER | |||
| PF-382 | Growth Inhibition Assay | IC50=0.58379 μM | SANGER | |||
| SH-4 | Growth Inhibition Assay | IC50=0.60509 μM | SANGER | |||
| no-10 | Growth Inhibition Assay | IC50=0.60813 μM | SANGER | |||
| KINGS-1 | Growth Inhibition Assay | IC50=0.62764 μM | SANGER | |||
| KE-37 | Growth Inhibition Assay | IC50=0.63942 μM | SANGER | |||
| TGBC1TKB | Growth Inhibition Assay | IC50=0.68642 μM | SANGER | |||
| NCI-H747 | Growth Inhibition Assay | IC50=0.71274 μM | SANGER | |||
| MONO-MAC-6 | Growth Inhibition Assay | IC50=0.7182 μM | SANGER | |||
| LC4-1 | Growth Inhibition Assay | IC50=0.74747 μM | SANGER | |||
| DSH1 | Growth Inhibition Assay | IC50=0.75792 μM | SANGER | |||
| OPM-2 | Growth Inhibition Assay | IC50=0.75837 μM | SANGER | |||
| CP66-MEL | Growth Inhibition Assay | IC50=0.83646 μM | SANGER | |||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.87076 μM | SANGER | |||
| EM-2 | Growth Inhibition Assay | IC50=0.87844 μM | SANGER | |||
| ONS-76 | Growth Inhibition Assay | IC50=0.89904 μM | SANGER | |||
| RKO | Growth Inhibition Assay | IC50=0.93176 μM | SANGER | |||
| RS4-11 | Growth Inhibition Assay | IC50=0.95567 μM | SANGER | |||
| KS-1 | Growth Inhibition Assay | IC50=0.97175 μM | SANGER | |||
| HEL | Growth Inhibition Assay | IC50=1.07025 μM | SANGER | |||
| LB771-HNC | Growth Inhibition Assay | IC50=1.07291 μM | SANGER | |||
| KGN | Growth Inhibition Assay | IC50=1.17566 μM | SANGER | |||
| NMC-G1 | Growth Inhibition Assay | IC50=1.18954 μM | SANGER | |||
| C2BBe1 | Growth Inhibition Assay | IC50=1.20033 μM | SANGER | |||
| HCC1599 | Growth Inhibition Assay | IC50=1.25589 μM | SANGER | |||
| TK10 | Growth Inhibition Assay | IC50=1.28397 μM | SANGER | |||
| IST-SL1 | Growth Inhibition Assay | IC50=1.30754 μM | SANGER | |||
| Raji | Growth Inhibition Assay | IC50=1.46531 μM | SANGER | |||
| KALS-1 | Growth Inhibition Assay | IC50=1.46658 μM | SANGER | |||
| BB49-HNC | Growth Inhibition Assay | IC50=1.49911 μM | SANGER | |||
| LB996-RCC | Growth Inhibition Assay | IC50=1.55279 μM | SANGER | |||
| NCI-H1092 | Growth Inhibition Assay | IC50=1.58368 μM | SANGER | |||
| DEL | Growth Inhibition Assay | IC50=1.5921 μM | SANGER | |||
| HT | Growth Inhibition Assay | IC50=1.70043 μM | SANGER | |||
| TE-5 | Growth Inhibition Assay | IC50=1.83901 μM | SANGER | |||
| RPMI-6666 | Growth Inhibition Assay | IC50=1.85897 μM | SANGER | |||
| JVM-2 | Growth Inhibition Assay | IC50=1.95209 μM | SANGER | |||
| Daudi | Growth Inhibition Assay | IC50=2.05459 μM | SANGER | |||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=2.07059 μM | SANGER | |||
| BL-41 | Growth Inhibition Assay | IC50=2.11804 μM | SANGER | |||
| OMC-1 | Growth Inhibition Assay | IC50=2.15065 μM | SANGER | |||
| HCC2157 | Growth Inhibition Assay | IC50=2.15677 μM | SANGER | |||
| MLMA | Growth Inhibition Assay | IC50=2.18576 μM | SANGER | |||
| LB373-MEL-D | Growth Inhibition Assay | IC50=2.23667 μM | SANGER | |||
| KURAMOCHI | Growth Inhibition Assay | IC50=2.25183 μM | SANGER | |||
| 697 | Growth Inhibition Assay | IC50=2.26226 μM | SANGER | |||
| KARPAS-422 | Growth Inhibition Assay | IC50=2.30393 μM | SANGER | |||
| CCRF-CEM | Growth Inhibition Assay | IC50=2.31255 μM | SANGER | |||
| A3-KAW | Growth Inhibition Assay | IC50=2.38186 μM | SANGER | |||
| KARPAS-299 | Growth Inhibition Assay | IC50=2.38967 μM | SANGER | |||
| LAMA-84 | Growth Inhibition Assay | IC50=2.45622 μM | SANGER | |||
| SCC-3 | Growth Inhibition Assay | IC50=2.47955 μM | SANGER | |||
| SW872 | Growth Inhibition Assay | IC50=2.60022 μM | SANGER | |||
| KNS-81-FD | Growth Inhibition Assay | IC50=2.67382 μM | SANGER | |||
| NCCIT | Growth Inhibition Assay | IC50=2.67795 μM | SANGER | |||
| ACN | Growth Inhibition Assay | IC50=2.84394 μM | SANGER | |||
| CAS-1 | Growth Inhibition Assay | IC50=2.86126 μM | SANGER | |||
| GB-1 | Growth Inhibition Assay | IC50=2.88421 μM | SANGER | |||
| EW-16 | Growth Inhibition Assay | IC50=2.98023 μM | SANGER | |||
| LB647-SCLC | Growth Inhibition Assay | IC50=3.0086 μM | SANGER | |||
| KM-H2 | Growth Inhibition Assay | IC50=3.14413 μM | SANGER | |||
| Becker | Growth Inhibition Assay | IC50=3.20254 μM | SANGER | |||
| MMAC-SF | Growth Inhibition Assay | IC50=3.21082 μM | SANGER | |||
| BC-1 | Growth Inhibition Assay | IC50=3.24287 μM | SANGER | |||
| GR-ST | Growth Inhibition Assay | IC50=3.59266 μM | SANGER | |||
| SCC-15 | Growth Inhibition Assay | IC50=3.59326 μM | SANGER | |||
| KP-N-YS | Growth Inhibition Assay | IC50=3.62126 μM | SANGER | |||
| A253 | Growth Inhibition Assay | IC50=3.76302 μM | SANGER | |||
| JiyoyeP-2003 | Growth Inhibition Assay | IC50=3.82083 μM | SANGER | |||
| LAN-6 | Growth Inhibition Assay | IC50=3.85926 μM | SANGER | |||
| VA-ES-BJ | Growth Inhibition Assay | IC50=3.96369 μM | SANGER | |||
| MPP-89 | Growth Inhibition Assay | IC50=3.98406 μM | SANGER | |||
| K-562 | Growth Inhibition Assay | IC50=3.9918 μM | SANGER | |||
| KASUMI-1 | Growth Inhibition Assay | IC50=3.99677 μM | SANGER | |||
| THP-1 | Growth Inhibition Assay | IC50=4.04835 μM | SANGER | |||
| DOHH-2 | Growth Inhibition Assay | IC50=4.06592 μM | SANGER | |||
| EW-1 | Growth Inhibition Assay | IC50=4.19255 μM | SANGER | |||
| K5 | Growth Inhibition Assay | IC50=4.26164 μM | SANGER | |||
| SR | Growth Inhibition Assay | IC50=4.3002 μM | SANGER | |||
| NCI-H719 | Growth Inhibition Assay | IC50=4.36265 μM | SANGER | |||
| A388 | Growth Inhibition Assay | IC50=4.39507 μM | SANGER | |||
| HCC2218 | Growth Inhibition Assay | IC50=4.44812 μM | SANGER | |||
| EB2 | Growth Inhibition Assay | IC50=4.5114 μM | SANGER | |||
| UACC-257 | Growth Inhibition Assay | IC50=4.51454 μM | SANGER | |||
| LC-1F | Growth Inhibition Assay | IC50=4.63784 μM | SANGER | |||
| NB1 | Growth Inhibition Assay | IC50=4.8413 μM | SANGER | |||
| NCI-H748 | Growth Inhibition Assay | IC50=4.90737 μM | SANGER | |||
| NALM-6 | Growth Inhibition Assay | IC50=4.92582 μM | SANGER | |||
| NB7 | Growth Inhibition Assay | IC50=5.04589 μM | SANGER | |||
| ECC4 | Growth Inhibition Assay | IC50=5.05273 μM | SANGER | |||
| no-11 | Growth Inhibition Assay | IC50=5.16913 μM | SANGER | |||
| COLO-824 | Growth Inhibition Assay | IC50=5.40415 μM | SANGER | |||
| LXF-289 | Growth Inhibition Assay | IC50=5.40704 μM | SANGER | |||
| MOLT-4 | Growth Inhibition Assay | IC50=5.48599 μM | SANGER | |||
| NCI-H1355 | Growth Inhibition Assay | IC50=5.63865 μM | SANGER | |||
| ATN-1 | Growth Inhibition Assay | IC50=5.76359 μM | SANGER | |||
| NOS-1 | Growth Inhibition Assay | IC50=5.85194 μM | SANGER | |||
| PSN1 | Growth Inhibition Assay | IC50=5.90945 μM | SANGER | |||
| NOMO-1 | Growth Inhibition Assay | IC50=5.99228 μM | SANGER | |||
| NCI-H23 | Growth Inhibition Assay | IC50=6.10875 μM | SANGER | |||
| LB1047-RCC | Growth Inhibition Assay | IC50=6.3288 μM | SANGER | |||
| ES8 | Growth Inhibition Assay | IC50=6.36816 μM | SANGER | |||
| LS-1034 | Growth Inhibition Assay | IC50=6.55658 μM | SANGER | |||
| MDA-MB-134-VI | Growth Inhibition Assay | IC50=6.64033 μM | SANGER | |||
| MZ1-PC | Growth Inhibition Assay | IC50=6.674 μM | SANGER | |||
| ES4 | Growth Inhibition Assay | IC50=6.92652 μM | SANGER | |||
| SNB75 | Growth Inhibition Assay | IC50=7.20588 μM | SANGER | |||
| P30-OHK | Growth Inhibition Assay | IC50=7.21282 μM | SANGER | |||
| Calu-6 | Growth Inhibition Assay | IC50=7.27563 μM | SANGER | |||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=7.32929 μM | SANGER | |||
| DU-4475 | Growth Inhibition Assay | IC50=7.57964 μM | SANGER | |||
| U-698-M | Growth Inhibition Assay | IC50=7.85992 μM | SANGER | |||
| IM-9 | Growth Inhibition Assay | IC50=8.12437 μM | SANGER | |||
| QIMR-WIL | Growth Inhibition Assay | IC50=8.13337 μM | SANGER | |||
| NB5 | Growth Inhibition Assay | IC50=8.23226 μM | SANGER | |||
| RPMI-8402 | Growth Inhibition Assay | IC50=8.27928 μM | SANGER | |||
| MZ2-MEL | Growth Inhibition Assay | IC50=8.46677 μM | SANGER | |||
| SK-MEL-2 | Growth Inhibition Assay | IC50=8.5574 μM | SANGER | |||
| NCI-H69 | Growth Inhibition Assay | IC50=8.79201 μM | SANGER | |||
| CMK | Growth Inhibition Assay | IC50=8.84538 μM | SANGER | |||
| MV-4-11 | Growth Inhibition Assay | IC50=8.86801 μM | SANGER | |||
| MEG-01 | Growth Inhibition Assay | IC50=8.88154 μM | SANGER | |||
| NCI-H1581 | Growth Inhibition Assay | IC50=9.15716 μM | SANGER | |||
| MZ7-mel | Growth Inhibition Assay | IC50=9.27307 μM | SANGER | |||
| SJSA-1 | Growth Inhibition Assay | IC50=9.52951 μM | SANGER | |||
| SKM-1 | Growth Inhibition Assay | IC50=9.61824 μM | SANGER | |||
| YT | Growth Inhibition Assay | IC50=9.83673 μM | SANGER | |||
| LS-123 | Growth Inhibition Assay | IC50=10.1011 μM | SANGER | |||
| NCI-H720 | Growth Inhibition Assay | IC50=10.2198 μM | SANGER | |||
| NH-12 | Growth Inhibition Assay | IC50=10.2432 μM | SANGER | |||
| NKM-1 | Growth Inhibition Assay | IC50=10.5981 μM | SANGER | |||
| HUTU-80 | Growth Inhibition Assay | IC50=10.616 μM | SANGER | |||
| TUR | Growth Inhibition Assay | IC50=10.8222 μM | SANGER | |||
| NB14 | Growth Inhibition Assay | IC50=11.7876 μM | SANGER | |||
| CESS | Growth Inhibition Assay | IC50=12.0629 μM | SANGER | |||
| ES5 | Growth Inhibition Assay | IC50=12.1105 μM | SANGER | |||
| EB-3 | Growth Inhibition Assay | IC50=12.4485 μM | SANGER | |||
| SNU-C1 | Growth Inhibition Assay | IC50=12.6517 μM | SANGER | |||
| CA46 | Growth Inhibition Assay | IC50=12.9298 μM | SANGER | |||
| NCI-H1304 | Growth Inhibition Assay | IC50=13.0111 μM | SANGER | |||
| NCI-H1522 | Growth Inhibition Assay | IC50=13.2394 μM | SANGER | |||
| ST486 | Growth Inhibition Assay | IC50=13.3147 μM | SANGER | |||
| D-263MG | Growth Inhibition Assay | IC50=13.565 μM | SANGER | |||
| L-540 | Growth Inhibition Assay | IC50=13.6084 μM | SANGER | |||
| LOUCY | Growth Inhibition Assay | IC50=13.7564 μM | SANGER | |||
| EW-3 | Growth Inhibition Assay | IC50=13.8253 μM | SANGER | |||
| HCC1187 | Growth Inhibition Assay | IC50=13.8349 μM | SANGER | |||
| KU812 | Growth Inhibition Assay | IC50=14.0902 μM | SANGER | |||
| NCI-H1963 | Growth Inhibition Assay | IC50=14.1004 μM | SANGER | |||
| SCH | Growth Inhibition Assay | IC50=14.1615 μM | SANGER | |||
| NCI-H1417 | Growth Inhibition Assay | IC50=14.3226 μM | SANGER | |||
| NCI-H2081 | Growth Inhibition Assay | IC50=14.5781 μM | SANGER | |||
| WSU-NHL | Growth Inhibition Assay | IC50=14.6373 μM | SANGER | |||
| CGTH-W-1 | Growth Inhibition Assay | IC50=15.0867 μM | SANGER | |||
| TE-12 | Growth Inhibition Assay | IC50=15.1938 μM | SANGER | |||
| OCUB-M | Growth Inhibition Assay | IC50=15.3376 μM | SANGER | |||
| ES3 | Growth Inhibition Assay | IC50=15.6556 μM | SANGER | |||
| GOTO | Growth Inhibition Assay | IC50=15.8269 μM | SANGER | |||
| SW962 | Growth Inhibition Assay | IC50=15.8866 μM | SANGER | |||
| BC-3 | Growth Inhibition Assay | IC50=16.566 μM | SANGER | |||
| GT3TKB | Growth Inhibition Assay | IC50=17.0105 μM | SANGER | |||
| SK-N-DZ | Growth Inhibition Assay | IC50=17.1644 μM | SANGER | |||
| LU-65 | Growth Inhibition Assay | IC50=17.6506 μM | SANGER | |||
| EC-GI-10 | Growth Inhibition Assay | IC50=18.0735 μM | SANGER | |||
| ARH-77 | Growth Inhibition Assay | IC50=18.3741 μM | SANGER | |||
| BB65-RCC | Growth Inhibition Assay | IC50=18.5752 μM | SANGER | |||
| NCI-H1648 | Growth Inhibition Assay | IC50=18.6376 μM | SANGER | |||
| SK-NEP-1 | Growth Inhibition Assay | IC50=18.7023 μM | SANGER | |||
| NCI-H64 | Growth Inhibition Assay | IC50=18.944 μM | SANGER | |||
| TE-15 | Growth Inhibition Assay | IC50=18.9815 μM | SANGER | |||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=19.3517 μM | SANGER | |||
| ES7 | Growth Inhibition Assay | IC50=19.46 μM | SANGER | |||
| NCI-H2141 | Growth Inhibition Assay | IC50=19.5619 μM | SANGER | |||
| U-87-MG | Growth Inhibition Assay | IC50=19.6307 μM | SANGER | |||
| GAK | Growth Inhibition Assay | IC50=19.7956 μM | SANGER | |||
| TE-9 | Growth Inhibition Assay | IC50=20.0459 μM | SANGER | |||
| TE-1 | Growth Inhibition Assay | IC50=20.8915 μM | SANGER | |||
| DMS-79 | Growth Inhibition Assay | IC50=20.9557 μM | SANGER | |||
| GDM-1 | Growth Inhibition Assay | IC50=21.0468 μM | SANGER | |||
| NCI-H1650 | Growth Inhibition Assay | IC50=21.2129 μM | SANGER | |||
| D-283MED | Growth Inhibition Assay | IC50=21.4585 μM | SANGER | |||
| HD-MY-Z | Growth Inhibition Assay | IC50=22.3294 μM | SANGER | |||
| EW-13 | Growth Inhibition Assay | IC50=22.4135 μM | SANGER | |||
| 8-MG-BA | Growth Inhibition Assay | IC50=22.956 μM | SANGER | |||
| A498 | Growth Inhibition Assay | IC50=23.2708 μM | SANGER | |||
| NCI-H524 | Growth Inhibition Assay | IC50=23.8942 μM | SANGER | |||
| D-247MG | Growth Inhibition Assay | IC50=23.9489 μM | SANGER | |||
| IST-MES1 | Growth Inhibition Assay | IC50=24.239 μM | SANGER | |||
| NCI-H1838 | Growth Inhibition Assay | IC50=24.9878 μM | SANGER | |||
| SK-UT-1 | Growth Inhibition Assay | IC50=25.1851 μM | SANGER | |||
| LS-513 | Growth Inhibition Assay | IC50=25.5136 μM | SANGER | |||
| MHH-NB-11 | Growth Inhibition Assay | IC50=25.9507 μM | SANGER | |||
| TALL-1 | Growth Inhibition Assay | IC50=26.5085 μM | SANGER | |||
| RCC10RGB | Growth Inhibition Assay | IC50=26.5486 μM | SANGER | |||
| L-363 | Growth Inhibition Assay | IC50=26.6166 μM | SANGER | |||
| MC-CAR | Growth Inhibition Assay | IC50=26.6901 μM | SANGER | |||
| KNS-42 | Growth Inhibition Assay | IC50=26.8177 μM | SANGER | |||
| LB2518-MEL | Growth Inhibition Assay | IC50=27.479 μM | SANGER | |||
| SF126 | Growth Inhibition Assay | IC50=27.6883 μM | SANGER | |||
| BV-173 | Growth Inhibition Assay | IC50=27.8955 μM | SANGER | |||
| C8166 | Growth Inhibition Assay | IC50=27.9353 μM | SANGER | |||
| SU-DHL-1 | Growth Inhibition Assay | IC50=28.9415 μM | SANGER | |||
| LP-1 | Growth Inhibition Assay | IC50=29.1543 μM | SANGER | |||
| SK-PN-DW | Growth Inhibition Assay | IC50=29.2129 μM | SANGER | |||
| RL95-2 | Growth Inhibition Assay | IC50=29.5637 μM | SANGER | |||
| GCIY | Growth Inhibition Assay | IC50=29.7428 μM | SANGER | |||
| NCI-H1770 | Growth Inhibition Assay | IC50=29.9399 μM | SANGER | |||
| KY821 | Growth Inhibition Assay | IC50=30.5434 μM | SANGER | |||
| NB13 | Growth Inhibition Assay | IC50=30.9584 μM | SANGER | |||
| BB30-HNC | Growth Inhibition Assay | IC50=31.0823 μM | SANGER | |||
| EW-24 | Growth Inhibition Assay | IC50=32.3473 μM | SANGER | |||
| GI-1 | Growth Inhibition Assay | IC50=33.7814 μM | SANGER | |||
| OVCAR-4 | Growth Inhibition Assay | IC50=34.065 μM | SANGER | |||
| HC-1 | Growth Inhibition Assay | IC50=34.4958 μM | SANGER | |||
| NCI-H209 | Growth Inhibition Assay | IC50=34.7578 μM | SANGER | |||
| COLO-829 | Growth Inhibition Assay | IC50=35.1091 μM | SANGER | |||
| NCI-H1395 | Growth Inhibition Assay | IC50=35.8459 μM | SANGER | |||
| HOP-62 | Growth Inhibition Assay | IC50=36.8021 μM | SANGER | |||
| NCI-H2171 | Growth Inhibition Assay | IC50=36.9848 μM | SANGER | |||
| LS-411N | Growth Inhibition Assay | IC50=36.9919 μM | SANGER | |||
| ETK-1 | Growth Inhibition Assay | IC50=37.05 μM | SANGER | |||
| KMOE-2 | Growth Inhibition Assay | IC50=37.2234 μM | SANGER | |||
| EKVX | Growth Inhibition Assay | IC50=37.3946 μM | SANGER | |||
| SF539 | Growth Inhibition Assay | IC50=38.6705 μM | SANGER | |||
| RL | Growth Inhibition Assay | IC50=38.6818 μM | SANGER | |||
| MOLT-16 | Growth Inhibition Assay | IC50=38.9944 μM | SANGER | |||
| NCI-H128 | Growth Inhibition Assay | IC50=39.5567 μM | SANGER | |||
| SHP-77 | Growth Inhibition Assay | IC50=39.7722 μM | SANGER | |||
| EVSA-T | Growth Inhibition Assay | IC50=40.0164 μM | SANGER | |||
| DB | Growth Inhibition Assay | IC50=40.4441 μM | SANGER | |||
| TE-441-T | Growth Inhibition Assay | IC50=40.7601 μM | SANGER | |||
| NCI-SNU-16 | Growth Inhibition Assay | IC50=40.7771 μM | SANGER | |||
| ALL-PO | Growth Inhibition Assay | IC50=40.8264 μM | SANGER | |||
| P31-FUJ | Growth Inhibition Assay | IC50=41.0485 μM | SANGER | |||
| EW-24 | Growth Inhibition Assay | IC50=41.4224 μM | SANGER | |||
| LC-2-ad | Growth Inhibition Assay | IC50=41.7115 μM | SANGER | |||
| AM-38 | Growth Inhibition Assay | IC50=43.4398 μM | SANGER | |||
| COLO-684 | Growth Inhibition Assay | IC50=43.4687 μM | SANGER | |||
| L-428 | Growth Inhibition Assay | IC50=44.6708 μM | SANGER | |||
| RXF393 | Growth Inhibition Assay | IC50=44.7331 μM | SANGER | |||
| MRK-nu-1 | Growth Inhibition Assay | IC50=45.9253 μM | SANGER | |||
| TE-10 | Growth Inhibition Assay | IC50=46.4915 μM | SANGER | |||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=46.5661 μM | SANGER | |||
| NCI-H1694 | Growth Inhibition Assay | IC50=46.8105 μM | SANGER | |||
| A4-Fuk | Growth Inhibition Assay | IC50=47.7106 μM | SANGER | |||
| REH | Growth Inhibition Assay | IC50=47.8793 μM | SANGER | |||
| CAL-148 | Growth Inhibition Assay | IC50=49.101 μM | SANGER | |||
| KARPAS-45 | Growth Inhibition Assay | IC50=51.0359 μM | SANGER | |||
| NEC8 | Growth Inhibition Assay | IC50=51.178 μM | SANGER | |||
| NCI-H446 | Growth Inhibition Assay | IC50=54.3092 μM | SANGER | |||
| SF268 | Growth Inhibition Assay | IC50=56.4043 μM | SANGER | |||
| EoL-1-cell | Growth Inhibition Assay | IC50=57.0315 μM | SANGER | |||
| IST-MEL1 | Growth Inhibition Assay | IC50=58.6442 μM | SANGER | |||
| OS-RC-2 | Growth Inhibition Assay | IC50=58.6841 μM | SANGER | |||
| BL-70 | Growth Inhibition Assay | IC50=58.8002 μM | SANGER | |||
| GI-ME-N | Growth Inhibition Assay | IC50=59.7717 μM | SANGER | |||
| SK-LMS-1 | Growth Inhibition Assay | IC50=60.4282 μM | SANGER | |||
| RH-1 | Growth Inhibition Assay | IC50=61.2697 μM | SANGER | |||
| D-336MG | Growth Inhibition Assay | IC50=61.2933 μM | SANGER | |||
| NCI-H2196 | Growth Inhibition Assay | IC50=62.2931 μM | SANGER | |||
| IST-SL2 | Growth Inhibition Assay | IC50=65.0102 μM | SANGER | |||
| DG-75 | Growth Inhibition Assay | IC50=65.873 μM | SANGER | |||
| SK-MEL-1 | Growth Inhibition Assay | IC50=66.8299 μM | SANGER | |||
| SK-N-FI | Growth Inhibition Assay | IC50=67.97 μM | SANGER | |||
| SCLC-21H | Growth Inhibition Assay | IC50=69.6286 μM | SANGER | |||
| KM12 | Growth Inhibition Assay | IC50=70.1607 μM | SANGER | |||
| TE-6 | Growth Inhibition Assay | IC50=71.6266 μM | SANGER | |||
| HCE-T | Growth Inhibition Assay | IC50=72.7372 μM | SANGER | |||
| ES1 | Growth Inhibition Assay | IC50=75.1944 μM | SANGER | |||
| SK-MM-2 | Growth Inhibition Assay | IC50=75.8461 μM | SANGER | |||
| SW954 | Growth Inhibition Assay | IC50=78.0688 μM | SANGER | |||
| LU-139 | Growth Inhibition Assay | IC50=78.4739 μM | SANGER | |||
| SBC-1 | Growth Inhibition Assay | IC50=79.7008 μM | SANGER | |||
| K052 | Growth Inhibition Assay | IC50=81.9603 μM | SANGER | |||
| SIG-M5 | Growth Inhibition Assay | IC50=82.9596 μM | SANGER | |||
| TGW | Growth Inhibition Assay | IC50=84.6867 μM | SANGER | |||
| LU-134-A | Growth Inhibition Assay | IC50=85.9404 μM | SANGER | |||
| OCI-AML2 | Growth Inhibition Assay | IC50=86.8607 μM | SANGER | |||
| LOXIMVI | Growth Inhibition Assay | IC50=88.1676 μM | SANGER | |||
| MC116 | Growth Inhibition Assay | IC50=88.8718 μM | SANGER | |||
| JAR | Growth Inhibition Assay | IC50=89.0582 μM | SANGER | |||
| BT-474 | Growth Inhibition Assay | IC50=97.7609 μM | SANGER | |||
| IMR-5 | Growth Inhibition Assay | IC50=99.7585 μM | SANGER | |||
| HL-60 | Growth Inhibition Assay | IC50=102.901 μM | SANGER | |||
| NCI-H1882 | Growth Inhibition Assay | IC50=103.457 μM | SANGER | |||
| NB17 | Growth Inhibition Assay | IC50=106.528 μM | SANGER | |||
| NCI-H2126 | Growth Inhibition Assay | IC50=107.635 μM | SANGER | |||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=108.33 μM | SANGER | |||
| NB69 | Growth Inhibition Assay | IC50=112.333 μM | SANGER | |||
| JVM-3 | Growth Inhibition Assay | IC50=113.512 μM | SANGER | |||
| NCI-H226 | Growth Inhibition Assay | IC50=114.376 μM | SANGER | |||
| CTV-1 | Growth Inhibition Assay | IC50=115.234 μM | SANGER | |||
| KMS-12-PE | Growth Inhibition Assay | IC50=115.583 μM | SANGER | |||
| DMS-153 | Growth Inhibition Assay | IC50=117.411 μM | SANGER | |||
| NCI-H1436 | Growth Inhibition Assay | IC50=118.868 μM | SANGER | |||
| DJM-1 | Growth Inhibition Assay | IC50=119.978 μM | SANGER | |||
| CTB-1 | Growth Inhibition Assay | IC50=123.948 μM | SANGER | |||
| RPMI-8866 | Growth Inhibition Assay | IC50=134.232 μM | SANGER | |||
| NB6 | Growth Inhibition Assay | IC50=135.081 μM | SANGER | |||
| NCI-H510A | Growth Inhibition Assay | IC50=135.852 μM | SANGER | |||
| HAL-01 | Growth Inhibition Assay | IC50=136.429 μM | SANGER | |||
| COLO-668 | Growth Inhibition Assay | IC50=136.607 μM | SANGER | |||
| NB10 | Growth Inhibition Assay | IC50=139.732 μM | SANGER | |||
| U-266 | Growth Inhibition Assay | IC50=146.561 μM | SANGER | |||
| D-502MG | Growth Inhibition Assay | IC50=148.717 μM | SANGER | |||
| HDLM-2 | Growth Inhibition Assay | IC50=165.958 μM | SANGER | |||
| MN-60 | Growth Inhibition Assay | IC50=167.261 μM | SANGER | |||
| SW684 | Growth Inhibition Assay | IC50=182.57 μM | SANGER | |||
| COR-L279 | Growth Inhibition Assay | IC50=186.961 μM | SANGER | |||
| CPC-N | Growth Inhibition Assay | IC50=188.945 μM | SANGER | |||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=201.087 μM | SANGER | |||
| COLO-320-HSR | Growth Inhibition Assay | IC50=209.004 μM | SANGER | |||
| NCI-H889 | Growth Inhibition Assay | IC50=209.602 μM | SANGER | |||
| MHH-CALL-2 | Growth Inhibition Assay | IC50=230.298 μM | SANGER | |||
| COR-L88 | Growth Inhibition Assay | IC50=231.162 μM | SANGER | |||
| CHP-126 | Growth Inhibition Assay | IC50=237.146 μM | SANGER | |||
| NCI-H82 | Growth Inhibition Assay | IC50=240.731 μM | SANGER | |||
| SUP-T1 | Growth Inhibition Assay | IC50=243.062 μM | SANGER | |||
| NCI-H345 | Growth Inhibition Assay | IC50=246.503 μM | SANGER | |||
| LU-165 | Growth Inhibition Assay | IC50=247.336 μM | SANGER | |||
| DMS-114 | Growth Inhibition Assay | IC50=253.811 μM | SANGER | |||
| NCI-H716 | Growth Inhibition Assay | IC50=259.637 μM | SANGER | |||
| SIMA | Growth Inhibition Assay | IC50=312.028 μM | SANGER | |||
| NCI-H526 | Growth Inhibition Assay | IC50=312.685 μM | SANGER | |||
| NH-12 | Growth Inhibition Assay | IC50=316.901 μM | SANGER | |||
| MS-1 | Growth Inhibition Assay | IC50=327.666 μM | SANGER | |||
| MFM-223 | Growth Inhibition Assay | IC50=340.486 μM | SANGER | |||
| EW-11 | Growth Inhibition Assay | IC50=348.123 μM | SANGER | |||
| KG-1 | Growth Inhibition Assay | IC50=387.778 μM | SANGER | |||
| NCI-H1155 | Growth Inhibition Assay | IC50=414.626 μM | SANGER | |||
| NCI-H187 | Growth Inhibition Assay | IC50=428.541 μM | SANGER | |||
| MSTO-211H | Growth Inhibition Assay | IC50=434.624 μM | SANGER | |||
| NCI-H322M | Growth Inhibition Assay | IC50=452.677 μM | SANGER | |||
| CW-2 | Growth Inhibition Assay | IC50=483.609 μM | SANGER | |||
| COLO-800 | Growth Inhibition Assay | IC50=525.413 μM | SANGER | |||
| EW-12 | Growth Inhibition Assay | IC50=557.847 μM | SANGER | |||
| EW-18 | Growth Inhibition Assay | IC50=672.665 μM | SANGER | |||
| Click to View More Cell Line Experimental Data | ||||||
Biological Activity
| Description | MG132 ((S,R,S)-(-)-MG132, Z-Leu-D-Leu-Leu-al) is a potent proteasome (ChTL, TL, and PGPH) inhibitor. MG132 also inhibits calpain (IC50=1.2 μM). | ||
|---|---|---|---|
| Targets |
|
| In vitro | ||||
| In vitro | MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an optimal concentration of 20 nM, displaying 500 times more potency than ZLLal. [1] MG-132 (10 μM) potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. [2] MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. [3] Unlike BzLLLCOCHO or PS-341, MG-132 treatment results in weak inhibition of the chymotrypsinlike (CT-L) and peptidylglutamyl peptide hydrolysing (PGPH) activities of the 26S proteasome, whereas multiple myeloma cells (U266 and OPM-2) are more sensitive to induction of apoptosis by MG-132 than BzLLLCOCHO. [4] MG-132 (1 μM) sensitizes TRAIL-resistant prostate cancer cells by activating the AP-1 family members c-Fos and c-Jun, which, in turn, repress the antiapoptotic molecule c-FLIP(L). [5] MG-132 significantly enhances the ability of inositol hexakisphosphate (IP6) to reduce cellular metabolic activity in both PC3 and DU145 androgen-independent prostate cancer (AIPCa) cell lines. [6] |
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|---|---|---|---|---|
| Kinase Assay | Measurement of inhibitory activities of MG-132 against 20S proteasome | |||
| The reaction mixture for the 20S proteasome inhibitory assay contains 0.1 M Tris-acetate, pH 7.0, 20S proteasome, MG-132, and 25 μM substrate dissolved in dimethyl sulfoxide in a final volume of 1 mL. After incuba tion at 37 °C for 15 minutes, the reaction is stopped by the addition of 0.1 mL of 10% SDS and 0.9 mL of 0.1M Tris acetate, pH 9.0. The fluorescence of the reaction products is measured. To determine the IC50 against 20S proteasome, various concentrations of MG-132 are included in the assay mixture. | ||||
| Cell Research | Cell lines | KIM-2, HC11, and ES | ||
| Concentrations | Dissolved in DMSO, final concentrations ~25 μM | |||
| Incubation Time | 24 and 48 hours | |||
| Method | Cells are exposed to various concentrations of MG-132 for 24, and 48 hours. Supernatant and monolayer cells are harvested by centrifugation and fixed in 70% ethanol in PBS for staining with acridine orange. Equal volumes of cells and acridine orange (5 mg/mL in PBS) are mixed on a microscope slide and examined by fluorescence microscopy. For annexin V analysis, cells are harvested by centrifugation and stained with annexin V and propidium iodide. For cell cycle analysis, cells are rehydrated in PBS at room temperature for 10 minutes, followed by staining with propidium iodide (5 mg/mL). All samples are analyzed using a Coulter Epics XL flow cytometer. |
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| Experimental Result Images | Methods | Biomarkers | Images | PMID |
| Western Blot | Bcr-Abl Ac-histone H3 Cleaved-caspase3 Cleaved-PARP ASCL1 CgA Nrf2 HO-1 |
|
26722260 | |
| Immunofluorescence | C2GnT-M / NMIIA AGS3 / Vimentin Bak |
|
22525330 | |
| Growth inhibition assay | Apoptosis assay Cell viability cell proliferation |
|
20557369 | |
| ELISA | IL-8 IL-1beta |
|
11160671 | |
| In Vivo | ||
| In vivo | Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, β-dystroglycan, α-bdystroglycan, and α-sarcoglycan in skeletal muscle fibers from mdx mice, reduces muscle membrane damage, and ameliorates the histopathological signs of muscular dystrophy. [7] MG-132 treatment significantly reduces immobilization-induced skeletal muscle atrophy in mice, by downregulating the muscle-specific ubiquitin ligases atrogin-1/MAFbx and MuRF-1 mRNA. [8] |
|
|---|---|---|
| Animal Research | Animal Models | Male mdx (C57BL/10ScSn DMD mdx) mice |
| Dosages | ~10 μg/kg/day | |
| Administration | Injection | |
Chemical Information & Solubility
| Molecular Weight | 475.62 | Formula | C26H41N3O5 |
| CAS No. | 1211877-36-9 | SDF | Download MG132 SDF |
| Smiles | CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 | ||
| Storage (From the date of receipt) | |||
|
In vitro |
DMSO : 95 mg/mL ( (199.73 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Ethanol : 95 mg/mL Water : Insoluble |
Molecular Weight Calculator |
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In vivo Add solvents to the product individually and in order. |
In vivo Formulation Calculator |
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Preparing Stock Solutions
Molarity Calculator
In vivo Formulation Calculator (Clear solution)
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
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Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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Frequently Asked Questions
Question 1:
I want to know whether it contains EDTA or other chelating agent in this product(S2619)?
Answer:
Our S2619 MG-132 doesn't contain EDTA or other chelating agent.
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