Home Transmembrane Transporters NKCC

NKCC

Other Transmembrane Transporters Related Inhibitors

CFTR CRM1 Calcium Channel Proton Pump P-gp Sodium Channel ATPase Potassium Channel CD markers GLUT
Cat.No. Product Name Information Product Use Citations Product Validations
S1603 Furosemide Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used in the treatment of congestive heart failure and edema.
J Immunother Cancer, 2024, 12(11)e009805
Ren Fail, 2022, 44(1):1345-1355
Environ Toxicol Chem, 2021, 10.1002/etc.5018
S1287 Bumetanide Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. This compound is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.
J Immunother Cancer, 2024, 12(11)e009805
PLoS Pathog, 2024, 20(10):e1012601
Cancer Med, 2024, 13(11):e7291
S5194 Furosemide sodium Furosemide (Frusemide) sodium is a potent and orally active inhibitor of Na-K-Cl cotransporter (NKCC). Furosemide sodium is a subtype-selective antagonist of gamma-aminobutyric acid type A (GABAA) receptor.
Nat Commun, 2024, 15(1):7342
Ren Fail, 2022, 44(1):1345-1355
E2358 Azosemide Azosemide is a potent Na+–K+–2Cl− cotransporter NKCC1 inhibitor with IC50s of 0.246 µM for hNKCC1A and 0.197 µM for NKCC1B, respectively.
S8615 Sodium Dichloroacetate (DCA) DCA (Sodium dichloroacetate), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.
bioRxiv, 2025, 2025.04.03.647023
bioRxiv, 2025, 2025.08.24.671623
bioRxiv, 2025, 2023.08.11.552890