Home Transmembrane Transporters NKCC inhibitor - GABA Receptor antagonist Furosemide sodium For research use only.

Furosemide sodium

Synonyms: Lasix, Frusemide Sodium

Furosemide (Frusemide) sodium is a potent and orally active inhibitor of Na-K-Cl cotransporter (NKCC). Furosemide sodium is a subtype-selective antagonist of gamma-aminobutyric acid type A (GABAA) receptor.

Furosemide sodium Chemical Structure

Furosemide sodium Chemical Structure

CAS No. 41733-55-5

Purity & Quality Control

Batch: S519401 DMSO]71 mg/mL]false]Water]71 mg/mL]false]Ethanol]Insoluble]false Purity: 99.96%
99.96

Furosemide sodium Related Products

Biological Activity

Description Furosemide (Frusemide) sodium is a potent and orally active inhibitor of Na-K-Cl cotransporter (NKCC). Furosemide sodium is a subtype-selective antagonist of gamma-aminobutyric acid type A (GABAA) receptor.
Targets
NKCC [1] GABAA receptor [2]
In vitro
In vitro

Furosemide reversibly alters the responses to tones and clicks of the chinchilla basilar membrane in hair cells, causing response-magnitude reductions that are largest (up to 61 dB, averaging 25-30 dB) at low stimulus intensities at the characteristic frequency (CF) and small or nonexistent at high intensities and at frequencies far removed from CF. Furosemide also induces response-phase lags that are largest at low stimulus intensities (averaging 77 degrees) and are confined to frequencies close to CF. [1] Furosemide concentration- and time-dependently increases the formation of nitric oxide andprostacyclin. Furosemide leads to an enhanced release of kinins into the supernatant of the cells. [2] Furosemide reversibly suppresses low Ca2+-induced epileptiform activity in hippocampus proper and blocks or significantly reduces different types of epileptiform discharges in the low Mg2+ model and the 4-aminopyridine model. [3] Furosemide significantly inhibits cell growth in MKN45 cells, but not in MKN28 cells. Furosemide diminishes cell growth by delaying the G(1)-S phase progression in poorly differentiated gastric adenocarcinoma cells, which show high expression and activity of NKCC, but not in moderately differentiated gastric adenocarcinoma cells with low expression and NKCC activity. [4]
In Vivo
In vivo

Furosemide (0.25 to 2 mg/kg), administered 4 hours before exercise, reduces right atrial pressure (RAP) and pulmonary arterial pressure (PAP) during exercise in dose-dependent manner in horse. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06251778 Recruiting
Amyloidosis|Amyloidosis Cardiac|ATTR Amyloidosis Wild Type
Paolo Milani|IRCCS Policlinico S. Matteo
 January 26 2024 --
NCT06105255 Active not recruiting
Healthy Male
InventisBio Co. Ltd
 May 24 2023 Phase 1
NCT05915286 Suspended
End Stage Renal Disease on Dialysis
University of Alberta
 May 29 2023 Phase 4
NCT05881603 Recruiting
Cardiogenic Acute Pulmonary Edema
Centre Hospitalier Universitaire de la Réunion
 May 20 2023 --

Chemical Information & Solubility

Molecular Weight 352.73 Formula

C12H10ClN2NaO5S
CAS No. 41733-55-5 SDF --
Smiles [Na+].N[S](=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C([O-])=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 71 mg/mL ( (201.28 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 71 mg/mL

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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