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Bumetanide

Name: Bumetanide
Brand: Selleck Chemicals
SKU: S1287
Rating: 5 (2 reviews)

Synonyms: Ro 10-6338，PF 1593

Catalog No.S1287 Purity:99.99%

Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.

Bumetanide Chemical Structure

CAS No. 28395-03-1

Purity & Quality Control

Batch: Purity: 99.99%

99.99

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Biological Activity

Description	Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05753059	Recruiting	Heart Failure	Yale University\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	August 10 2023	Phase 1
NCT05323487	Recruiting	Heart Failure	Yale University	June 1 2022	Not Applicable
NCT02582476	Terminated	Hypokalemic Periodic Paralysis	University College London	January 2015	Phase 2
NCT00830531	Completed	Seizures	Soul Janet M.D.\|Citizens United for Research in Epilepsy\|Harvard Catalyst- Harvard Clinical and Translational Science Center\|Translational Research Program Boston Children''s Hospital\|Charles H. Hood Foundation\|National Institute of Neurological Disorders and Stroke (NINDS)\|Mooney Family Initiative for Translational Studies in Rare Diseases Boston Children''s Hospital	January 2010	Phase 1
NCT00930865	Completed	Type 2 Diabetes Mellitus	AstraZeneca\|Bristol-Myers Squibb	July 2009	Phase 1

Chemical Information & Solubility

Molecular Weight	364.42	Formula	C₁₇H₂₀N₂O₅S
CAS No.	28395-03-1	SDF	Download Bumetanide SDF
Smiles	CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 73 mg/mL ( (200.31 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 12 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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